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In Support of Clinical Case Reports: A System of Causality Assessment

The usefulness of clinical research depends on an assessment of causality. This assessment determines what constitutes clinical evidence. Case reports are an example of evidence that is frequently overlooked because it is believed they cannot address causal links between treatment and outcomes. This...

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Detalles Bibliográficos
Autores principales: Kiene, Helmut, Hamre, Harald J., Kienle, Gunver S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Global Advances in Health and Medicine 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3833527/
https://www.ncbi.nlm.nih.gov/pubmed/24416665
http://dx.doi.org/10.7453/gahmj.2012.061
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author Kiene, Helmut
Hamre, Harald J.
Kienle, Gunver S.
author_facet Kiene, Helmut
Hamre, Harald J.
Kienle, Gunver S.
author_sort Kiene, Helmut
collection PubMed
description The usefulness of clinical research depends on an assessment of causality. This assessment determines what constitutes clinical evidence. Case reports are an example of evidence that is frequently overlooked because it is believed they cannot address causal links between treatment and outcomes. This may be a mistake. Clarity on the topic of causality and its assessment will be of benefit for researchers and clinicians. This article outlines an overall system of causality and causality assessment. The system proposed involves two dimensions: horizontal and vertical; each of these dimensions consists of three different types of causality and three corresponding types of causality assessment. Included in this system are diverse forms of case causality illustrated with examples from everyday life and clinical medicine. Assessing case causality can complement conventional clinical research in an era of personalized medicine.
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spelling pubmed-38335272014-03-01 In Support of Clinical Case Reports: A System of Causality Assessment Kiene, Helmut Hamre, Harald J. Kienle, Gunver S. Glob Adv Health Med Methodology Review The usefulness of clinical research depends on an assessment of causality. This assessment determines what constitutes clinical evidence. Case reports are an example of evidence that is frequently overlooked because it is believed they cannot address causal links between treatment and outcomes. This may be a mistake. Clarity on the topic of causality and its assessment will be of benefit for researchers and clinicians. This article outlines an overall system of causality and causality assessment. The system proposed involves two dimensions: horizontal and vertical; each of these dimensions consists of three different types of causality and three corresponding types of causality assessment. Included in this system are diverse forms of case causality illustrated with examples from everyday life and clinical medicine. Assessing case causality can complement conventional clinical research in an era of personalized medicine. Global Advances in Health and Medicine 2013-03 2013-03-01 /pmc/articles/PMC3833527/ /pubmed/24416665 http://dx.doi.org/10.7453/gahmj.2012.061 Text en © 2013 GAHM LLC. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial- No Derivative 3.0 License, which permits rights to copy, distribute and transmit the work for noncommercial purposes only, provided the original work is properly cited.
spellingShingle Methodology Review
Kiene, Helmut
Hamre, Harald J.
Kienle, Gunver S.
In Support of Clinical Case Reports: A System of Causality Assessment
title In Support of Clinical Case Reports: A System of Causality Assessment
title_full In Support of Clinical Case Reports: A System of Causality Assessment
title_fullStr In Support of Clinical Case Reports: A System of Causality Assessment
title_full_unstemmed In Support of Clinical Case Reports: A System of Causality Assessment
title_short In Support of Clinical Case Reports: A System of Causality Assessment
title_sort in support of clinical case reports: a system of causality assessment
topic Methodology Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3833527/
https://www.ncbi.nlm.nih.gov/pubmed/24416665
http://dx.doi.org/10.7453/gahmj.2012.061
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