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High Serum Levels of Pro-Brain Natriuretic Peptide (pro BNP) Identify Cardioembolic Origin in Undetermined Stroke
Background: Stroke subtype diagnosis leads to specific therapies to reduce recurrences. Because nearly one third of patients remain with unknown etiology after a complete screening workup, we aim to investigate whether molecular markers of myocardial damage were associated with cardioembolic stroke...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
IOS Press
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3833699/ https://www.ncbi.nlm.nih.gov/pubmed/19729800 http://dx.doi.org/10.3233/DMA-2009-0630 |
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author | Rodríguez-Yáñez, Manuel Sobrino, Tomás Blanco, Miguel de la Ossa, Natalia Pérez Brea, David Rodríguez-González, Raquel Leira, Rogelio Dávalos, Antonio Castillo, José |
author_facet | Rodríguez-Yáñez, Manuel Sobrino, Tomás Blanco, Miguel de la Ossa, Natalia Pérez Brea, David Rodríguez-González, Raquel Leira, Rogelio Dávalos, Antonio Castillo, José |
author_sort | Rodríguez-Yáñez, Manuel |
collection | PubMed |
description | Background: Stroke subtype diagnosis leads to specific therapies to reduce recurrences. Because nearly one third of patients remain with unknown etiology after a complete screening workup, we aim to investigate whether molecular markers of myocardial damage were associated with cardioembolic stroke and if they were useful to reclassify strokes of undetermined etiology. Methods: We included 262 patients with first ischemic stroke within the first 12 hours. Stroke subtype was evaluated by TOAST criteria. Stroke of undetermined origin were reclassified into likely atherothrombotic or likely cardioembolic according to a predefined non-validated algorithm. Blood samples were obtained on admission to determine serum levels of molecular markers (pro-BNP, pro-ANP and CK-MB) of myocardial damage. Results: Patients with cardioembolic infarct showed higher levels of pro-BNP, pro-ANP and CK-MB. Pro-BNP > 360 pg/mL was independently associated with cardioembolic stroke (OR: 28.51, CI95%: 5.90–136.75, p < 0.0001). Stroke etiology was undetermined in 82 patients (31%); 34 were reclassified as likely cardioembolic, 22 as likely atherothrombotic, and 26 remained as undetermined. Pro-BNP > 360 pg/mL was the only factor independently associated with likely cardioembolic stroke. Conclusions: Pro-BNP levels higher than 360 pg/mL are associated with cardioembolic stroke and may be useful to reclassify undetermined strokes as of cardioembolic origin. |
format | Online Article Text |
id | pubmed-3833699 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | IOS Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-38336992013-12-10 High Serum Levels of Pro-Brain Natriuretic Peptide (pro BNP) Identify Cardioembolic Origin in Undetermined Stroke Rodríguez-Yáñez, Manuel Sobrino, Tomás Blanco, Miguel de la Ossa, Natalia Pérez Brea, David Rodríguez-González, Raquel Leira, Rogelio Dávalos, Antonio Castillo, José Dis Markers Other Background: Stroke subtype diagnosis leads to specific therapies to reduce recurrences. Because nearly one third of patients remain with unknown etiology after a complete screening workup, we aim to investigate whether molecular markers of myocardial damage were associated with cardioembolic stroke and if they were useful to reclassify strokes of undetermined etiology. Methods: We included 262 patients with first ischemic stroke within the first 12 hours. Stroke subtype was evaluated by TOAST criteria. Stroke of undetermined origin were reclassified into likely atherothrombotic or likely cardioembolic according to a predefined non-validated algorithm. Blood samples were obtained on admission to determine serum levels of molecular markers (pro-BNP, pro-ANP and CK-MB) of myocardial damage. Results: Patients with cardioembolic infarct showed higher levels of pro-BNP, pro-ANP and CK-MB. Pro-BNP > 360 pg/mL was independently associated with cardioembolic stroke (OR: 28.51, CI95%: 5.90–136.75, p < 0.0001). Stroke etiology was undetermined in 82 patients (31%); 34 were reclassified as likely cardioembolic, 22 as likely atherothrombotic, and 26 remained as undetermined. Pro-BNP > 360 pg/mL was the only factor independently associated with likely cardioembolic stroke. Conclusions: Pro-BNP levels higher than 360 pg/mL are associated with cardioembolic stroke and may be useful to reclassify undetermined strokes as of cardioembolic origin. IOS Press 2009 2009-09-03 /pmc/articles/PMC3833699/ /pubmed/19729800 http://dx.doi.org/10.3233/DMA-2009-0630 Text en Copyright © 2009 Hindawi Publishing Corporation. |
spellingShingle | Other Rodríguez-Yáñez, Manuel Sobrino, Tomás Blanco, Miguel de la Ossa, Natalia Pérez Brea, David Rodríguez-González, Raquel Leira, Rogelio Dávalos, Antonio Castillo, José High Serum Levels of Pro-Brain Natriuretic Peptide (pro BNP) Identify Cardioembolic Origin in Undetermined Stroke |
title | High Serum Levels of Pro-Brain Natriuretic Peptide (pro BNP) Identify Cardioembolic Origin in Undetermined Stroke |
title_full | High Serum Levels of Pro-Brain Natriuretic Peptide (pro BNP) Identify Cardioembolic Origin in Undetermined Stroke |
title_fullStr | High Serum Levels of Pro-Brain Natriuretic Peptide (pro BNP) Identify Cardioembolic Origin in Undetermined Stroke |
title_full_unstemmed | High Serum Levels of Pro-Brain Natriuretic Peptide (pro BNP) Identify Cardioembolic Origin in Undetermined Stroke |
title_short | High Serum Levels of Pro-Brain Natriuretic Peptide (pro BNP) Identify Cardioembolic Origin in Undetermined Stroke |
title_sort | high serum levels of pro-brain natriuretic peptide (pro bnp) identify cardioembolic origin in undetermined stroke |
topic | Other |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3833699/ https://www.ncbi.nlm.nih.gov/pubmed/19729800 http://dx.doi.org/10.3233/DMA-2009-0630 |
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