Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples

Detection of somatic point substitutions is a key step in characterizing the cancer genome. Mutations in cancer are rare (0.1–100/Mb) and often occur only in a subset of the sequenced cells, either due to contamination by normal cells or due to tumor heterogeneity. Consequently, mutation calling met...

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Detalles Bibliográficos
Autores principales: Cibulskis, Kristian, Lawrence, Michael S., Carter, Scott L., Sivachenko, Andrey, Jaffe, David, Sougnez, Carrie, Gabriel, Stacey, Meyerson, Matthew, Lander, Eric S., Getz, Gad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3833702/
https://www.ncbi.nlm.nih.gov/pubmed/23396013
http://dx.doi.org/10.1038/nbt.2514

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3833702/
https://www.ncbi.nlm.nih.gov/pubmed/23396013
http://dx.doi.org/10.1038/nbt.2514

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