Cargando…

Myocardial Biomarkers for Prediction of Cardiovascular Disease

The identification of those persons in the population who have the highest risk of future cardiovascular events is important for targeting intensive preventive efforts. This can be reliably done using a handful of long since established risk factors. The unmet need for new molecular biomarkers for p...

Descripción completa

Detalles Bibliográficos
Autor principal: Sundström, Johan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3833709/
https://www.ncbi.nlm.nih.gov/pubmed/19773613
http://dx.doi.org/10.3233/DMA-2009-0635
_version_ 1782291882871619584
author Sundström, Johan
author_facet Sundström, Johan
author_sort Sundström, Johan
collection PubMed
description The identification of those persons in the population who have the highest risk of future cardiovascular events is important for targeting intensive preventive efforts. This can be reliably done using a handful of long since established risk factors. The unmet need for new molecular biomarkers for prediction of cardiovascular events in the general population is therefore low. In order for a new biomarker to be used clinically for risk prediction, a statistically significant association of levels of the biomarker to adverse outcome is not enough, but the biomarker should also be demonstrated to add discriminative capacity beyond established risk factors. In contrast to the limited value of new biomarkers for risk prediction, their usefulness for unraveling the pathophysiology of cardiovascular disease is large. The myocardium is the source of a vast number of interesting biomarkers, of which a few may be useful for risk prediction in the general population. Two of these, troponin-I and the N-terminal fragment of brain natriuretic peptide, have passed tests of added discriminatory value. Numerous other biomarkers produced by cardiomyocytes or non-cardiomyocytes in the myocardium are promising, and if they are not proven useful for risk prediction, they will unquestionably enhance our understanding of cardiovascular disease.
format Online
Article
Text
id pubmed-3833709
institution National Center for Biotechnology Information
language English
publishDate 2009
publisher IOS Press
record_format MEDLINE/PubMed
spelling pubmed-38337092013-12-10 Myocardial Biomarkers for Prediction of Cardiovascular Disease Sundström, Johan Dis Markers Other The identification of those persons in the population who have the highest risk of future cardiovascular events is important for targeting intensive preventive efforts. This can be reliably done using a handful of long since established risk factors. The unmet need for new molecular biomarkers for prediction of cardiovascular events in the general population is therefore low. In order for a new biomarker to be used clinically for risk prediction, a statistically significant association of levels of the biomarker to adverse outcome is not enough, but the biomarker should also be demonstrated to add discriminative capacity beyond established risk factors. In contrast to the limited value of new biomarkers for risk prediction, their usefulness for unraveling the pathophysiology of cardiovascular disease is large. The myocardium is the source of a vast number of interesting biomarkers, of which a few may be useful for risk prediction in the general population. Two of these, troponin-I and the N-terminal fragment of brain natriuretic peptide, have passed tests of added discriminatory value. Numerous other biomarkers produced by cardiomyocytes or non-cardiomyocytes in the myocardium are promising, and if they are not proven useful for risk prediction, they will unquestionably enhance our understanding of cardiovascular disease. IOS Press 2009 2009-09-21 /pmc/articles/PMC3833709/ /pubmed/19773613 http://dx.doi.org/10.3233/DMA-2009-0635 Text en Copyright © 2009 Hindawi Publishing Corporation.
spellingShingle Other
Sundström, Johan
Myocardial Biomarkers for Prediction of Cardiovascular Disease
title Myocardial Biomarkers for Prediction of Cardiovascular Disease
title_full Myocardial Biomarkers for Prediction of Cardiovascular Disease
title_fullStr Myocardial Biomarkers for Prediction of Cardiovascular Disease
title_full_unstemmed Myocardial Biomarkers for Prediction of Cardiovascular Disease
title_short Myocardial Biomarkers for Prediction of Cardiovascular Disease
title_sort myocardial biomarkers for prediction of cardiovascular disease
topic Other
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3833709/
https://www.ncbi.nlm.nih.gov/pubmed/19773613
http://dx.doi.org/10.3233/DMA-2009-0635
work_keys_str_mv AT sundstromjohan myocardialbiomarkersforpredictionofcardiovasculardisease