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Mechanism of Allosteric Activation of SAMHD1 by dGTP

SAMHD1, a deoxyribonucleoside triphosphate triphosphohydrolase (dNTPase), plays a key role in human innate immunity. It inhibits infection of blood cells by retroviruses, including HIV, and prevents the development of the autoinflammatory Aicardi-Goutières syndrome (AGS). The inactive apo-SAMHD1 int...

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Detalles Bibliográficos
Autores principales:	Ji, Xiaoyun, Wu, Ying, Yan, Junpeng, Mehrens, Jennifer, Yang, Haitao, DeLucia, Maria, Hao, Caili, Gronenborn, Angela M., Skowronski, Jacek, Ahn, Jinwoo, Xiong, Yong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3833828/ https://www.ncbi.nlm.nih.gov/pubmed/24141705 http://dx.doi.org/10.1038/nsmb.2692

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