Decreased plasticity of coreceptor use by CD4-independent SIV Envs that emerge in vivo

BACKGROUND: HIV and SIV generally require CD4 binding prior to coreceptor engagement, but Env can acquire the ability to use CCR5 independently of CD4 under various circumstances. The ability to use CCR5 coupled with low-to-absent CD4 levels is associated with enhanced macrophage infection and incre...

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Detalles Bibliográficos
Autores principales: Francella, Nicholas, Elliott, Sarah TC, Yi, Yanjie, Gwyn, Sarah E, Ortiz, Alexandra M, Li, Bing, Silvestri, Guido, Paiardini, Mirko, Derdeyn, Cynthia A, Collman, Ronald G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3833851/
https://www.ncbi.nlm.nih.gov/pubmed/24219995
http://dx.doi.org/10.1186/1742-4690-10-133

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