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Corosolic acid enhances the antitumor effects of chemotherapy on epithelial ovarian cancer by inhibiting signal transducer and activator of transcription 3 signaling
Resistance to chemotherapy poses a serious problem for the treatment of advanced epithelial ovarian cancer patients. The mechanisms of chemoresistance are complex and studies have implicated signal transducer and activator of transcription 3 (STAT3) signaling in the chemoresistance of cancer cells....
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3834045/ https://www.ncbi.nlm.nih.gov/pubmed/24260055 http://dx.doi.org/10.3892/ol.2013.1591 |
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author | FUJIWARA, YUKIO TAKAISHI, KIYOMI NAKAO, JUNKO IKEDA, TSUYOSHI KATABUCHI, HIDETAKA TAKEYA, MOTOHIRO KOMOHARA, YOSHIHIRO |
author_facet | FUJIWARA, YUKIO TAKAISHI, KIYOMI NAKAO, JUNKO IKEDA, TSUYOSHI KATABUCHI, HIDETAKA TAKEYA, MOTOHIRO KOMOHARA, YOSHIHIRO |
author_sort | FUJIWARA, YUKIO |
collection | PubMed |
description | Resistance to chemotherapy poses a serious problem for the treatment of advanced epithelial ovarian cancer patients. The mechanisms of chemoresistance are complex and studies have implicated signal transducer and activator of transcription 3 (STAT3) signaling in the chemoresistance of cancer cells. The present study investigated whether corosolic acid (CA), which has been previously reported to be a STAT3 inhibitor, was able to increase the sensitivity to chemotherapeutic drugs in epithelial ovarian cancer cells. CA also markedly enhanced the anticancer effect of paclitaxel, cisplatin and doxorubicin. In addition, CA abrogated the cell-cell interactions between macrophages and epithelial ovarian cancer cells and inhibited the macrophage-induced activation of epithelial ovarian cancer cells. These data indicated that CA was able to reverse the chemoresistance of epithelial ovarian cancer cells and suppress the cell-cell interaction with tumorigenic macrophages. Thus, CA may be useful as an adjuvant treatment to patients with advanced ovarian and other types of cancer due to the multiple anticancer effects. |
format | Online Article Text |
id | pubmed-3834045 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-38340452013-11-20 Corosolic acid enhances the antitumor effects of chemotherapy on epithelial ovarian cancer by inhibiting signal transducer and activator of transcription 3 signaling FUJIWARA, YUKIO TAKAISHI, KIYOMI NAKAO, JUNKO IKEDA, TSUYOSHI KATABUCHI, HIDETAKA TAKEYA, MOTOHIRO KOMOHARA, YOSHIHIRO Oncol Lett Articles Resistance to chemotherapy poses a serious problem for the treatment of advanced epithelial ovarian cancer patients. The mechanisms of chemoresistance are complex and studies have implicated signal transducer and activator of transcription 3 (STAT3) signaling in the chemoresistance of cancer cells. The present study investigated whether corosolic acid (CA), which has been previously reported to be a STAT3 inhibitor, was able to increase the sensitivity to chemotherapeutic drugs in epithelial ovarian cancer cells. CA also markedly enhanced the anticancer effect of paclitaxel, cisplatin and doxorubicin. In addition, CA abrogated the cell-cell interactions between macrophages and epithelial ovarian cancer cells and inhibited the macrophage-induced activation of epithelial ovarian cancer cells. These data indicated that CA was able to reverse the chemoresistance of epithelial ovarian cancer cells and suppress the cell-cell interaction with tumorigenic macrophages. Thus, CA may be useful as an adjuvant treatment to patients with advanced ovarian and other types of cancer due to the multiple anticancer effects. D.A. Spandidos 2013-12 2013-09-18 /pmc/articles/PMC3834045/ /pubmed/24260055 http://dx.doi.org/10.3892/ol.2013.1591 Text en Copyright © 2013, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
spellingShingle | Articles FUJIWARA, YUKIO TAKAISHI, KIYOMI NAKAO, JUNKO IKEDA, TSUYOSHI KATABUCHI, HIDETAKA TAKEYA, MOTOHIRO KOMOHARA, YOSHIHIRO Corosolic acid enhances the antitumor effects of chemotherapy on epithelial ovarian cancer by inhibiting signal transducer and activator of transcription 3 signaling |
title | Corosolic acid enhances the antitumor effects of chemotherapy on epithelial ovarian cancer by inhibiting signal transducer and activator of transcription 3 signaling |
title_full | Corosolic acid enhances the antitumor effects of chemotherapy on epithelial ovarian cancer by inhibiting signal transducer and activator of transcription 3 signaling |
title_fullStr | Corosolic acid enhances the antitumor effects of chemotherapy on epithelial ovarian cancer by inhibiting signal transducer and activator of transcription 3 signaling |
title_full_unstemmed | Corosolic acid enhances the antitumor effects of chemotherapy on epithelial ovarian cancer by inhibiting signal transducer and activator of transcription 3 signaling |
title_short | Corosolic acid enhances the antitumor effects of chemotherapy on epithelial ovarian cancer by inhibiting signal transducer and activator of transcription 3 signaling |
title_sort | corosolic acid enhances the antitumor effects of chemotherapy on epithelial ovarian cancer by inhibiting signal transducer and activator of transcription 3 signaling |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3834045/ https://www.ncbi.nlm.nih.gov/pubmed/24260055 http://dx.doi.org/10.3892/ol.2013.1591 |
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