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Diets Containing Sea Cucumber (Isostichopus badionotus) Meals Are Hypocholesterolemic in Young Rats
Sea cucumber is widely consumed as a putative functional food. It contains many biologically-active substances, but only limited research on its properties in vivo has been done. The effects of different meals containing Isostichopus badionotus, a sea cucumber from southeast Mexico, on growth perfor...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3834158/ https://www.ncbi.nlm.nih.gov/pubmed/24260223 http://dx.doi.org/10.1371/journal.pone.0079446 |
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author | Olivera-Castillo, Leticia Davalos, Alberto Grant, George Valadez-Gonzalez, Nina Montero, Jorge Barrera-Perez, Hirian Alonso Moshe Chim-Chi, Yasser Olvera-Novoa, Miguel Angel Ceja-Moreno, Víctor Acereto-Escoffie, Pablo Rubio-Piña, Jorge Rodriguez-Canul, Rossanna |
author_facet | Olivera-Castillo, Leticia Davalos, Alberto Grant, George Valadez-Gonzalez, Nina Montero, Jorge Barrera-Perez, Hirian Alonso Moshe Chim-Chi, Yasser Olvera-Novoa, Miguel Angel Ceja-Moreno, Víctor Acereto-Escoffie, Pablo Rubio-Piña, Jorge Rodriguez-Canul, Rossanna |
author_sort | Olivera-Castillo, Leticia |
collection | PubMed |
description | Sea cucumber is widely consumed as a putative functional food. It contains many biologically-active substances, but only limited research on its properties in vivo has been done. The effects of different meals containing Isostichopus badionotus, a sea cucumber from southeast Mexico, on growth performance and body lipid profile in young rats were analyzed. Sea cucumber body wall was either lyophilized, cooked (100 °C, 1 h in water) and lyophilized, or oven-dried (70 °C for 12 h). It was then ground and incorporated into cholesterol-containing diets. I. badionotus meals supported growth and improved lipid profile in rats. In particular, serum cholesterol, low density lipoproteins, triglycerides concentration and atherogenic index values were greatly reduced by some I. badionotus containing diets. Liver total lipids, triglycerides and cholesterol were also reduced. Cooking or heat-treatment of the meals lowered but did not abolish their hypolipidemic potency. Gene expression analysis of several key genes involved in cholesterol and lipid metabolism in liver showed that diets containing I. badionotus repressed the induction of key genes associated with dyslipidemia exerted by cholesterol supplementation. Consumption of I. badionotus from the Yucatan Peninsula is beneficial for dyslipidemia, although biological effect is clearly dependent on preparation method. |
format | Online Article Text |
id | pubmed-3834158 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-38341582013-11-20 Diets Containing Sea Cucumber (Isostichopus badionotus) Meals Are Hypocholesterolemic in Young Rats Olivera-Castillo, Leticia Davalos, Alberto Grant, George Valadez-Gonzalez, Nina Montero, Jorge Barrera-Perez, Hirian Alonso Moshe Chim-Chi, Yasser Olvera-Novoa, Miguel Angel Ceja-Moreno, Víctor Acereto-Escoffie, Pablo Rubio-Piña, Jorge Rodriguez-Canul, Rossanna PLoS One Research Article Sea cucumber is widely consumed as a putative functional food. It contains many biologically-active substances, but only limited research on its properties in vivo has been done. The effects of different meals containing Isostichopus badionotus, a sea cucumber from southeast Mexico, on growth performance and body lipid profile in young rats were analyzed. Sea cucumber body wall was either lyophilized, cooked (100 °C, 1 h in water) and lyophilized, or oven-dried (70 °C for 12 h). It was then ground and incorporated into cholesterol-containing diets. I. badionotus meals supported growth and improved lipid profile in rats. In particular, serum cholesterol, low density lipoproteins, triglycerides concentration and atherogenic index values were greatly reduced by some I. badionotus containing diets. Liver total lipids, triglycerides and cholesterol were also reduced. Cooking or heat-treatment of the meals lowered but did not abolish their hypolipidemic potency. Gene expression analysis of several key genes involved in cholesterol and lipid metabolism in liver showed that diets containing I. badionotus repressed the induction of key genes associated with dyslipidemia exerted by cholesterol supplementation. Consumption of I. badionotus from the Yucatan Peninsula is beneficial for dyslipidemia, although biological effect is clearly dependent on preparation method. Public Library of Science 2013-11-19 /pmc/articles/PMC3834158/ /pubmed/24260223 http://dx.doi.org/10.1371/journal.pone.0079446 Text en © 2013 Olivera-Castillo et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Olivera-Castillo, Leticia Davalos, Alberto Grant, George Valadez-Gonzalez, Nina Montero, Jorge Barrera-Perez, Hirian Alonso Moshe Chim-Chi, Yasser Olvera-Novoa, Miguel Angel Ceja-Moreno, Víctor Acereto-Escoffie, Pablo Rubio-Piña, Jorge Rodriguez-Canul, Rossanna Diets Containing Sea Cucumber (Isostichopus badionotus) Meals Are Hypocholesterolemic in Young Rats |
title | Diets Containing Sea Cucumber (Isostichopus badionotus) Meals Are Hypocholesterolemic in Young Rats |
title_full | Diets Containing Sea Cucumber (Isostichopus badionotus) Meals Are Hypocholesterolemic in Young Rats |
title_fullStr | Diets Containing Sea Cucumber (Isostichopus badionotus) Meals Are Hypocholesterolemic in Young Rats |
title_full_unstemmed | Diets Containing Sea Cucumber (Isostichopus badionotus) Meals Are Hypocholesterolemic in Young Rats |
title_short | Diets Containing Sea Cucumber (Isostichopus badionotus) Meals Are Hypocholesterolemic in Young Rats |
title_sort | diets containing sea cucumber (isostichopus badionotus) meals are hypocholesterolemic in young rats |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3834158/ https://www.ncbi.nlm.nih.gov/pubmed/24260223 http://dx.doi.org/10.1371/journal.pone.0079446 |
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