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Frequency and Severity of Adverse Drug Reactions Due to Self-Medication: A Cross-Sectional Multicentre Survey in Emergency Departments

BACKGROUND: Little is known about the relation of adverse drug reactions (ADRs) to self-use of medications. OBJECTIVE: The aim of this study was to determine the frequency and severity of ADRs related to self-medication (ADR-SM) among emergency department (ED) patients and to describe their main cha...

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Autores principales: Asseray, Nathalie, Ballereau, Françoise, Trombert-Paviot, Béatrice, Bouget, Jacques, Foucher, Nadine, Renaud, Bertrand, Roulet, Lucien, Kierzek, Gerald, Armand-Perroux, Aurore, Potel, Gilles, Schmidt, Jeannot, Carpentier, Françoise, Queneau, Patrice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3834162/
https://www.ncbi.nlm.nih.gov/pubmed/24163273
http://dx.doi.org/10.1007/s40264-013-0114-y
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author Asseray, Nathalie
Ballereau, Françoise
Trombert-Paviot, Béatrice
Bouget, Jacques
Foucher, Nadine
Renaud, Bertrand
Roulet, Lucien
Kierzek, Gerald
Armand-Perroux, Aurore
Potel, Gilles
Schmidt, Jeannot
Carpentier, Françoise
Queneau, Patrice
author_facet Asseray, Nathalie
Ballereau, Françoise
Trombert-Paviot, Béatrice
Bouget, Jacques
Foucher, Nadine
Renaud, Bertrand
Roulet, Lucien
Kierzek, Gerald
Armand-Perroux, Aurore
Potel, Gilles
Schmidt, Jeannot
Carpentier, Françoise
Queneau, Patrice
author_sort Asseray, Nathalie
collection PubMed
description BACKGROUND: Little is known about the relation of adverse drug reactions (ADRs) to self-use of medications. OBJECTIVE: The aim of this study was to determine the frequency and severity of ADRs related to self-medication (ADR-SM) among emergency department (ED) patients and to describe their main characteristics. METHODS: A prospective, cross-sectional, observational study was conducted over a period of 8 weeks (1 March to 20 April 2010), in the ED of 11 French academic hospitals. Adult patients presenting to the ED during randomization periods were included, with the exception of cases of self-drug poisoning, inability to complete self-medication questionnaire, or refusal. Clinical outcomes were assessed as well as history of self-medication behaviours and all drugs taken. All doubtful files and those related to ADR-SM were systematically reviewed by an expert committee. RESULTS: A total of 3,027 of 4,661 patients presenting to the ED met the inclusion criteria. Of these, 84.4 % declared a self-medication behaviour, 63.7 % took at least one non-prescribed drug during the previous 2 weeks and 59.9 % took a prescribed medication. A total of 296 patients experienced an ADR (9.78 %), of which 52 (1.72 %) were related to self-medication. Those ADRs related to self-medication included prescribed drugs (n = 19), non-prescribed drugs (n = 17), treatment discontinuation (n = 14), and interactions between non-prescribed and prescribed drugs (n = 2). The ADRs attributed to non-prescribed drugs represented 1 % of all patients taking non-prescribed drugs (n = 1,927). ADR severity was significantly lower for those related to self-medication (p = .032). CONCLUSION: Self-medication is frequent; its potential toxicity should not be neglected, taking into account the rate of adverse drug reactions in about 1 % of ED patient. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s40264-013-0114-y) contains supplementary material, which is available to authorized users.
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spelling pubmed-38341622013-11-29 Frequency and Severity of Adverse Drug Reactions Due to Self-Medication: A Cross-Sectional Multicentre Survey in Emergency Departments Asseray, Nathalie Ballereau, Françoise Trombert-Paviot, Béatrice Bouget, Jacques Foucher, Nadine Renaud, Bertrand Roulet, Lucien Kierzek, Gerald Armand-Perroux, Aurore Potel, Gilles Schmidt, Jeannot Carpentier, Françoise Queneau, Patrice Drug Saf Short Communication BACKGROUND: Little is known about the relation of adverse drug reactions (ADRs) to self-use of medications. OBJECTIVE: The aim of this study was to determine the frequency and severity of ADRs related to self-medication (ADR-SM) among emergency department (ED) patients and to describe their main characteristics. METHODS: A prospective, cross-sectional, observational study was conducted over a period of 8 weeks (1 March to 20 April 2010), in the ED of 11 French academic hospitals. Adult patients presenting to the ED during randomization periods were included, with the exception of cases of self-drug poisoning, inability to complete self-medication questionnaire, or refusal. Clinical outcomes were assessed as well as history of self-medication behaviours and all drugs taken. All doubtful files and those related to ADR-SM were systematically reviewed by an expert committee. RESULTS: A total of 3,027 of 4,661 patients presenting to the ED met the inclusion criteria. Of these, 84.4 % declared a self-medication behaviour, 63.7 % took at least one non-prescribed drug during the previous 2 weeks and 59.9 % took a prescribed medication. A total of 296 patients experienced an ADR (9.78 %), of which 52 (1.72 %) were related to self-medication. Those ADRs related to self-medication included prescribed drugs (n = 19), non-prescribed drugs (n = 17), treatment discontinuation (n = 14), and interactions between non-prescribed and prescribed drugs (n = 2). The ADRs attributed to non-prescribed drugs represented 1 % of all patients taking non-prescribed drugs (n = 1,927). ADR severity was significantly lower for those related to self-medication (p = .032). CONCLUSION: Self-medication is frequent; its potential toxicity should not be neglected, taking into account the rate of adverse drug reactions in about 1 % of ED patient. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s40264-013-0114-y) contains supplementary material, which is available to authorized users. Springer International Publishing 2013-10-26 2013 /pmc/articles/PMC3834162/ /pubmed/24163273 http://dx.doi.org/10.1007/s40264-013-0114-y Text en © The Author(s) 2013 https://creativecommons.org/licenses/by-nc/2.5/ Open AccessThis article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Short Communication
Asseray, Nathalie
Ballereau, Françoise
Trombert-Paviot, Béatrice
Bouget, Jacques
Foucher, Nadine
Renaud, Bertrand
Roulet, Lucien
Kierzek, Gerald
Armand-Perroux, Aurore
Potel, Gilles
Schmidt, Jeannot
Carpentier, Françoise
Queneau, Patrice
Frequency and Severity of Adverse Drug Reactions Due to Self-Medication: A Cross-Sectional Multicentre Survey in Emergency Departments
title Frequency and Severity of Adverse Drug Reactions Due to Self-Medication: A Cross-Sectional Multicentre Survey in Emergency Departments
title_full Frequency and Severity of Adverse Drug Reactions Due to Self-Medication: A Cross-Sectional Multicentre Survey in Emergency Departments
title_fullStr Frequency and Severity of Adverse Drug Reactions Due to Self-Medication: A Cross-Sectional Multicentre Survey in Emergency Departments
title_full_unstemmed Frequency and Severity of Adverse Drug Reactions Due to Self-Medication: A Cross-Sectional Multicentre Survey in Emergency Departments
title_short Frequency and Severity of Adverse Drug Reactions Due to Self-Medication: A Cross-Sectional Multicentre Survey in Emergency Departments
title_sort frequency and severity of adverse drug reactions due to self-medication: a cross-sectional multicentre survey in emergency departments
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3834162/
https://www.ncbi.nlm.nih.gov/pubmed/24163273
http://dx.doi.org/10.1007/s40264-013-0114-y
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