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Investigation into CYP3A4-mediated drug–drug interactions on midostaurin in healthy volunteers

PURPOSE: Midostaurin (PKC412), a multitargeted tyrosine kinase inhibitor that targets FMS-related tyrosine kinase 3 and KIT, is in clinical trials for the treatment for acute myeloid leukemia and advanced systemic mastocytosis. In vitro studies showed that midostaurin is predominantly metabolized by...

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Detalles Bibliográficos
Autores principales:	Dutreix, Catherine, Munarini, Florence, Lorenzo, Sebastien, Roesel, Johannes, Wang, Yanfeng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2013
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3834177/ https://www.ncbi.nlm.nih.gov/pubmed/24085261 http://dx.doi.org/10.1007/s00280-013-2287-6

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