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High Resolution Crystal Structure of Human β-Glucuronidase Reveals Structural Basis of Lysosome Targeting

Human β-glucuronidase (GUS) cleaves β-D-glucuronic acid residues from the non-reducing termini of glycosaminoglycan and its deficiency leads to mucopolysaccharidosis type VII (MPSVII). Here we report a high resolution crystal structure of human GUS at 1.7 Å resolution and present an extensive analys...

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Detalles Bibliográficos
Autores principales:	Hassan, Md. Imtaiyaz, Waheed, Abdul, Grubb, Jeffery H., Klei, Herbert E., Korolev, Sergey, Sly, William S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3834196/ https://www.ncbi.nlm.nih.gov/pubmed/24260279 http://dx.doi.org/10.1371/journal.pone.0079687

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