Cisplatin Induces a Mitochondrial-ROS Response That Contributes to Cytotoxicity Depending on Mitochondrial Redox Status and Bioenergetic Functions

Cisplatin is one of the most effective and widely used anticancer agents for the treatment of several types of tumors. The cytotoxic effect of cisplatin is thought to be mediated primarily by the generation of nuclear DNA adducts, which, if not repaired, cause cell death as a consequence of DNA repl...

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Detalles Bibliográficos
Autores principales: Marullo, Rossella, Werner, Erica, Degtyareva, Natalya, Moore, Bryn, Altavilla, Giuseppe, Ramalingam, Suresh S., Doetsch, Paul W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3834214/
https://www.ncbi.nlm.nih.gov/pubmed/24260552
http://dx.doi.org/10.1371/journal.pone.0081162

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3834214/
https://www.ncbi.nlm.nih.gov/pubmed/24260552
http://dx.doi.org/10.1371/journal.pone.0081162

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