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Does docosahexaenoic acid supplementation in term infants enhance neurocognitive functioning in infancy?
The proposal that dietary docosahexaenoic acid (DHA) enhances neurocognitive functioning in term infants is controversial. Theoretical evidence, laboratory research and human epidemiological studies have convincingly demonstrated that DHA deficiency can negatively impact neurocognitive development....
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3834239/ https://www.ncbi.nlm.nih.gov/pubmed/24312040 http://dx.doi.org/10.3389/fnhum.2013.00774 |
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author | Heaton, Alexandra E. Meldrum, Suzanne J. Foster, Jonathan K. Prescott, Susan L. Simmer, Karen |
author_facet | Heaton, Alexandra E. Meldrum, Suzanne J. Foster, Jonathan K. Prescott, Susan L. Simmer, Karen |
author_sort | Heaton, Alexandra E. |
collection | PubMed |
description | The proposal that dietary docosahexaenoic acid (DHA) enhances neurocognitive functioning in term infants is controversial. Theoretical evidence, laboratory research and human epidemiological studies have convincingly demonstrated that DHA deficiency can negatively impact neurocognitive development. However, the results from randomized controlled trials (RCTs) of DHA supplementation in human term-born infants have been inconsistent. This article will (i) discuss the role of DHA in the human diet, (ii) explore the physiological mechanisms by which DHA plausibly influences neurocognitive capacity, and (iii) seek to characterize the optimal intake of DHA during infancy for neurocognitive functioning, based on existing research that has been undertaken in developed countries (specifically, within Australia). The major observational studies and RCTs that have examined dietary DHA in human infants and animals are presented, and we consider suggestions that DHA requirements vary across individuals according to genetic profile. It is important that the current evidence concerning DHA supplementation is carefully evaluated so that appropriate recommendations can be made and future directions of research can be strategically planned. |
format | Online Article Text |
id | pubmed-3834239 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-38342392013-12-05 Does docosahexaenoic acid supplementation in term infants enhance neurocognitive functioning in infancy? Heaton, Alexandra E. Meldrum, Suzanne J. Foster, Jonathan K. Prescott, Susan L. Simmer, Karen Front Hum Neurosci Neuroscience The proposal that dietary docosahexaenoic acid (DHA) enhances neurocognitive functioning in term infants is controversial. Theoretical evidence, laboratory research and human epidemiological studies have convincingly demonstrated that DHA deficiency can negatively impact neurocognitive development. However, the results from randomized controlled trials (RCTs) of DHA supplementation in human term-born infants have been inconsistent. This article will (i) discuss the role of DHA in the human diet, (ii) explore the physiological mechanisms by which DHA plausibly influences neurocognitive capacity, and (iii) seek to characterize the optimal intake of DHA during infancy for neurocognitive functioning, based on existing research that has been undertaken in developed countries (specifically, within Australia). The major observational studies and RCTs that have examined dietary DHA in human infants and animals are presented, and we consider suggestions that DHA requirements vary across individuals according to genetic profile. It is important that the current evidence concerning DHA supplementation is carefully evaluated so that appropriate recommendations can be made and future directions of research can be strategically planned. Frontiers Media S.A. 2013-11-20 /pmc/articles/PMC3834239/ /pubmed/24312040 http://dx.doi.org/10.3389/fnhum.2013.00774 Text en Copyright © 2013 Heaton, Meldrum, Foster, Prescott and Simmer. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Heaton, Alexandra E. Meldrum, Suzanne J. Foster, Jonathan K. Prescott, Susan L. Simmer, Karen Does docosahexaenoic acid supplementation in term infants enhance neurocognitive functioning in infancy? |
title | Does docosahexaenoic acid supplementation in term infants enhance neurocognitive functioning in infancy? |
title_full | Does docosahexaenoic acid supplementation in term infants enhance neurocognitive functioning in infancy? |
title_fullStr | Does docosahexaenoic acid supplementation in term infants enhance neurocognitive functioning in infancy? |
title_full_unstemmed | Does docosahexaenoic acid supplementation in term infants enhance neurocognitive functioning in infancy? |
title_short | Does docosahexaenoic acid supplementation in term infants enhance neurocognitive functioning in infancy? |
title_sort | does docosahexaenoic acid supplementation in term infants enhance neurocognitive functioning in infancy? |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3834239/ https://www.ncbi.nlm.nih.gov/pubmed/24312040 http://dx.doi.org/10.3389/fnhum.2013.00774 |
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