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Attenuation of VEGFR-2 Expression by sFlt-1 and Low Oxygen in Human Placenta

Vascular endothelial growth factor receptor 2 (VEGFR-2), the primary receptor for VEGF, is crucial for normal endothelial function. sFlt-1, a truncated and soluble form of VEGFR-1 which binds and inhibits VEGF, is increased in preeclampsia and is positively regulated by low oxygen. Here, we investig...

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Detalles Bibliográficos
Autores principales: Nevo, Ori, Lee, Dennis K., Caniggia, Isabella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3834253/
https://www.ncbi.nlm.nih.gov/pubmed/24260556
http://dx.doi.org/10.1371/journal.pone.0081176