Analysis of the Tolerance to DNA Alkylating Damage in MEC1 and RAD53 Checkpoint Mutants of Saccharomyces cerevisiae

Checkpoint response, tolerance and repair are three major pathways that eukaryotic cells evolved independently to maintain genome stability and integrity. Here, we studied the sensitivity to DNA damage in checkpoint-deficient budding yeast cells and found that checkpoint kinases Mec1 and Rad53 may m...

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Detalles Bibliográficos
Autores principales: Gallego-Sánchez, Alfonso, Ufano, Sandra, Andrés, Sonia, Bueno, Avelino
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3834268/
https://www.ncbi.nlm.nih.gov/pubmed/24260543
http://dx.doi.org/10.1371/journal.pone.0081108

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3834268/
https://www.ncbi.nlm.nih.gov/pubmed/24260543
http://dx.doi.org/10.1371/journal.pone.0081108

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