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N (6)-Substituted AMPs Inhibit Mammalian Deoxynucleotide N-Hydrolase DNPH1

The gene dnph1 (or rcl) encodes a hydrolase that cleaves the 2’-deoxyribonucleoside 5’-monophosphate (dNMP) N-glycosidic bond to yield a free nucleobase and 2-deoxyribose 5-phosphate. Recently, the crystal structure of rat DNPH1, a potential target for anti-cancer therapies, suggested that various a...

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Detalles Bibliográficos
Autores principales:	Amiable, Claire, Pochet, Sylvie, Padilla, André, Labesse, Gilles, Kaminski, Pierre Alexandre
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3834327/ https://www.ncbi.nlm.nih.gov/pubmed/24260472 http://dx.doi.org/10.1371/journal.pone.0080755

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