Skin Hydration and Collagen Synthesis of AF-343 in HS68 Cell Line and NC/Nga Mice by Filaggrin Expression and Suppression of Matrix Metallopreteinase

Extract of Taraxacum platycarpum (AF-343) has been reported to have several biological properties such as skin hydration and anti-inflammatory effects. Although clinical evidences of skin hydration and antiinflammatory effect were proven in clinical trial, precise mechanism of skin hydration was not...

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Detalles Bibliográficos
Autores principales: Cho, Jae-We, Jeong, Yeon-su, Han, Jiwon, Chun, Young-Jin, Kim, Hyun Kyu, Kim, Min Young, Kim, Beom Joon, Park, Ki Moon, Kim, Jong Keun, Kim, Jae Hyun, Cho, Soo-Muk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Toxicology 2011
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3834392/
https://www.ncbi.nlm.nih.gov/pubmed/24278576
http://dx.doi.org/10.5487/TR.2011.27.4.225
Descripción
Sumario:Extract of Taraxacum platycarpum (AF-343) has been reported to have several biological properties such as skin hydration and anti-inflammatory effects. Although clinical evidences of skin hydration and antiinflammatory effect were proven in clinical trial, precise mechanism of skin hydration was not fully understood yet. In this study, we have focused skin hydration mechanism related filaggrin, collagen, and matrix metalloproteinase (MMP) in vitro and animal study. Herein, skin hydration mechanism of AF-343 is due to recovery of filaggrin in mice model and increased production of collagen with suppression of matrix MMP in vitro fibroblast cell line.

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