The Safety Evaluation of a Potent Angiogenic Activator, Synthetic Peptide (SFKLRY-NH(2)) for the Skin Application

A novel synthetic hexapeptide (SFKLRY-NH(2)) that displays angiogenic activity has been identified by positional scanning of a synthetic peptide combinatorial library (PS-SPCL). This study was carried out to investigate the irritation of the SFKLRY-NH(2) on the skin. The tests were performed on the basis of Korea Food and Drug Administration (KFDA) guidelines. In results, cell toxicity is not appeared for SFKLRY-NH(2) in HaCaT cells and B16F10 cells. SFKLRY-NH(2) induced no skin irritation at low concentration (10 μM), mild irritation at high concentration (10mM). We consider that this result is helpful for saying about the safety of SFKLRY-NH(2) in clinical use.