Cargando…

Mouse Single Oral Dose Toxicity Test of Bupleuri Radix Aqueous Extracts

The aim of this study was to evaluate the single oral dose toxicity of Bupleuri Radix (BR) aqueous extracts, it has been traditionally used as anti-inflammatory agent, in male and female mice. BR extracts (yield = 16.52%) was administered to female and male ICR mice as an oral dose of 2,000, 1,000 a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kim, Kyung-Hu, Gam, Cheol-Ou, Choi, Seong-Hun, Ku, Sae-Kwang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Korean Society of Toxicology 2012
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3834400/ https://www.ncbi.nlm.nih.gov/pubmed/24278584 http://dx.doi.org/10.5487/TR.2012.28.1.011

Ejemplares similares

Single Oral Dose Toxicity Test of Platycodin D, a Saponin from Platycodin Radix in Mice
por: Lee, Won-Ho, et al.
Publicado: (2011)

Investigation on ultrasound assisted extraction of saikosaponins from Radix Bupleuri
por: Zhao, Shuna, et al.
Publicado: (2007)

Single Oral Dose Toxicity Study of Pinelliae Rhizoma Aqueous Extract in ICR Mice
por: Lim, Young-Kwon, et al.
Publicado: (2009)

Dose-Effect/Toxicity of Bupleuri Radix on Chronic Unpredictable Mild Stress and Normal Rats Based on Liver Metabolomics
por: Wang, Peng, et al.
Publicado: (2021)

A systematic review of the active saikosaponins and extracts isolated from Radix Bupleuri and their applications
por: Yuan, Bochuan, et al.
Publicado: (2016)

Mouse Single Oral Dose Toxicity Study of DHU001, a Polyherbal Formula
por: Roh, Seong-Soo, et al.
Publicado: (2010)

Ultrasensitive Time-Resolved Fluoroimmunoassay for Saikosaponin a in Chaihu (Bupleuri Radix)
por: Chao, Zhi, et al.
Publicado: (2016)

Clerosterol from vinegar-baked radix bupleuri modifies drug transport
por: Zhao, Ya, et al.
Publicado: (2017)

Systematic transcriptome analysis reveals molecular mechanisms and indications of bupleuri radix
por: Park, Sang-Min, et al.
Publicado: (2022)

Phylogenetic relationship and comparative analysis of the main Bupleuri Radix species in China
por: Wang, Ping, et al.
Publicado: (2023)

Comparative Effect of Aqueous and Methanolic Bupleuri Radix Extracts on Hepatic Uptake of High-Density Lipoprotein and Identification of the Potential Target in HFD-Fed Mice
por: Tan, Zhibin, et al.
Publicado: (2019)

Antioxidant and Proliferative Activities of Bupleuri Radix Extract Against Serum Deprivation in SH-SY5Y Cells
por: Seo, Mi Kyoung, et al.
Publicado: (2013)

Radix Bupleuri: A Review of Traditional Uses, Botany, Phytochemistry, Pharmacology, and Toxicology
por: Yang, Fude, et al.
Publicado: (2017)

Therapeutic effects of total saikosaponins from Radix bupleuri against Alzheimer’s disease
por: Li, Juan, et al.
Publicado: (2022)

Pharmacokinetic Evaluation of Clozapine in Concomitant Use of Radix Rehmanniae, Fructus Schisandrae, Radix Bupleuri, or Fructus Gardeniae in Rats
por: Tian, Dan-Dan, et al.
Publicado: (2016)

Simultaneous Extraction and Analysis of Seven Major Saikosaponins from Bupleuri Radix and the Exploration of Antioxidant Activity and Its Mechanism
por: Wang, Ning, et al.
Publicado: (2023)

Synergistic Effect of Bupleuri Radix and Scutellariae Radix on Adipogenesis and AMP-Activated Protein Kinase: A Network Pharmacological Approach
por: Lee, Jueun, et al.
Publicado: (2018)

Elucidation of the Anti-Inflammatory Mechanisms of Bupleuri and Scutellariae Radix Using System Pharmacological Analyses
por: Shen, Xia, et al.
Publicado: (2017)

Network-based pharmacology and molecular docking exploring the “Bupleuri Radix-Scutellariae Radix” mechanism of action in the viral hepatitis B treatment
por: Long, Piao, et al.
Publicado: (2022)

Radix Paeoniae Alba attenuates Radix Bupleuri-induced hepatotoxicity by modulating gut microbiota to alleviate the inhibition of saikosaponins on glutathione synthetase
por: Chen, Congcong, et al.
Publicado: (2023)

Vinegar amount in the process affected the components of vinegar-baked Radix Bupleuri and its hepatoprotective effect
por: Zhao, Ya, et al.
Publicado: (2016)

Identification of the original plants of cultivated Bupleuri Radix based on DNA barcoding and chloroplast genome analysis
por: Zhang, Gaixia, et al.
Publicado: (2022)

Single-Dose Oral Toxicity of Fermented Scutellariae Radix Extract in Rats and Dogs
por: Kim, Myoung-Seok, et al.
Publicado: (2012)

Bupleuri radix for Acute Uncomplicated Respiratory Tract Infection: A Systematic Review of Randomized Controlled Trials
por: Yan, Li-Jiao, et al.
Publicado: (2022)

A Network Pharmacology Study on the Active Components and Targets of the Radix Ginseng and Radix Bupleuri Herb Pair for Treating Nonalcoholic Fatty Liver Disease
por: Zhang, Qiang, et al.
Publicado: (2022)

Network pharmacology and molecular docking technology for exploring the effect and mechanism of Radix Bupleuri and Radix Paeoniae Alba herb-pair on anti-hepatitis: A review
por: Huang, Long, et al.
Publicado: (2023)

Vinegar-baked Radix Bupleuri modulates the cell membrane constituents and inhibits the P-gp activity in rat hepatocytes
por: Zhao, Ruizhi, et al.
Publicado: (2014)

Multielements determination and metal transfer investigation in herb medicine Bupleuri Radix by inductively coupled plasma‐mass spectrometry
por: Li, Kunlun, et al.
Publicado: (2018)

Comparative Study on Anti-Inflammatory Effect of Polysaccharides from Vinegar-Baked Radix Bupleuri Using Different Methods
por: Wei, Ni, et al.
Publicado: (2023)

Deciphering the Differential Effective and Toxic Responses of Bupleuri Radix following the Induction of Chronic Unpredictable Mild Stress and in Healthy Rats Based on Serum Metabolic Profiles
por: Gao, Xiaoxia, et al.
Publicado: (2018)

Studies on the Changes of Pharmacokinetics Behaviors of Phytochemicals and the Influence on Endogenous Metabolites After the Combination of Radix Bupleuri and Radix Paeoniae Alba Based on Multi-Component Pharmacokinetics and Metabolomics
por: Chen, Congcong, et al.
Publicado: (2021)

A 90-Day Repeated Oral Dose Toxicity Study of Alismatis Rhizoma Aqueous Extract in Rats
por: Lee, Mu-Jin, et al.
Publicado: (2019)

Comparison of Volatile Components between Raw and Vinegar Baked Radix Bupleuri by GC-MS Based Metabolic Fingerprinting Approach
por: Xing, Jie, et al.
Publicado: (2015)

Bupleuri Radix Prevents the Recurrences of Resected Colonic Polyps by Affecting Angiogenin-2-Induced Protein Kinase B/Akt Signaling
por: Gao, Qiang, et al.
Publicado: (2020)

Fermentation of Green Tea with 2% Aquilariae lignum Increases the Anti-Diabetic Activity of Green Tea Aqueous Extracts in the High Fat-Fed Mouse
por: Lee, Ji Eun, et al.
Publicado: (2015)

Study on the Identification of Radix Bupleuri from Its Unofficial Varieties Based on Discrete Wavelet Transformation Feature Extraction of ATR-FTIR Spectroscopy Combined with Probability Neural Network
por: Jin, Wenying, et al.
Publicado: (2015)

Risk of Liver Injury Associated with Chinese Herbal Products Containing Radix bupleuri in 639,779 Patients with Hepatitis B Virus Infection
por: Lee, Chang-Hsing, et al.
Publicado: (2011)

Quantitative Analysis and Differential Evaluation of Radix Bupleuri Cultivated in Different Regions Based on HPLC-MS and GC-MS Combined with Multivariate Statistical Analysis
por: Wang, Zhenhuan, et al.
Publicado: (2022)

Genotoxicity testing of Persicariae Rhizoma (Persicaria tinctoria H. Gross) aqueous extracts
por: LEE, WON HO, et al.
Publicado: (2016)

Oral Single Dose Toxicity Study of Low Molecular Fucoidan in Mice
por: Jung, Young-Mi, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_qcaekc259ro9ugb0t941jqqskc