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Post-Translational Modification of Proteins in Toxicological Research: Focus on Lysine Acylation

Toxicoproteomics integrates the proteomic knowledge into toxicology by enabling protein quantification in biofluids and tissues, thus taking toxicological research to the next level. Post-translational modification (PTM) alters the three-dimensional (3D) structure of proteins by covalently binding s...

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Detalles Bibliográficos
Autor principal: Lee, Sangkyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Toxicology 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3834447/
https://www.ncbi.nlm.nih.gov/pubmed/24278632
http://dx.doi.org/10.5487/TR.2013.29.2.081
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author Lee, Sangkyu
author_facet Lee, Sangkyu
author_sort Lee, Sangkyu
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description Toxicoproteomics integrates the proteomic knowledge into toxicology by enabling protein quantification in biofluids and tissues, thus taking toxicological research to the next level. Post-translational modification (PTM) alters the three-dimensional (3D) structure of proteins by covalently binding small molecules to them and therefore represents a major protein function diversification mechanism. Because of the crucial roles PTM plays in biological systems, the identification of novel PTMs and study of the role of PTMs are gaining much attention in proteomics research. Of the 300 known PTMs, protein acylation, including lysine formylation, acetylation, propionylation, butyrylation, malonylation, succinylation, and crotonylation, regulates the crucial functions of many eukaryotic proteins involved in cellular metabolism, cell cycle, aging, growth, angiogenesis, and cancer. Here, I reviewed recent studies regarding novel types of lysine acylation, their biological functions, and their applicationsin toxicoproteomics research.
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spelling pubmed-38344472013-11-25 Post-Translational Modification of Proteins in Toxicological Research: Focus on Lysine Acylation Lee, Sangkyu Toxicol Res Articles Toxicoproteomics integrates the proteomic knowledge into toxicology by enabling protein quantification in biofluids and tissues, thus taking toxicological research to the next level. Post-translational modification (PTM) alters the three-dimensional (3D) structure of proteins by covalently binding small molecules to them and therefore represents a major protein function diversification mechanism. Because of the crucial roles PTM plays in biological systems, the identification of novel PTMs and study of the role of PTMs are gaining much attention in proteomics research. Of the 300 known PTMs, protein acylation, including lysine formylation, acetylation, propionylation, butyrylation, malonylation, succinylation, and crotonylation, regulates the crucial functions of many eukaryotic proteins involved in cellular metabolism, cell cycle, aging, growth, angiogenesis, and cancer. Here, I reviewed recent studies regarding novel types of lysine acylation, their biological functions, and their applicationsin toxicoproteomics research. The Korean Society of Toxicology 2013-06 /pmc/articles/PMC3834447/ /pubmed/24278632 http://dx.doi.org/10.5487/TR.2013.29.2.081 Text en Copyright ©2013, The Korean Society of Toxicology http://creativecommons.org/licenses/by-nc/3.0/ This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Articles
Lee, Sangkyu
Post-Translational Modification of Proteins in Toxicological Research: Focus on Lysine Acylation
title Post-Translational Modification of Proteins in Toxicological Research: Focus on Lysine Acylation
title_full Post-Translational Modification of Proteins in Toxicological Research: Focus on Lysine Acylation
title_fullStr Post-Translational Modification of Proteins in Toxicological Research: Focus on Lysine Acylation
title_full_unstemmed Post-Translational Modification of Proteins in Toxicological Research: Focus on Lysine Acylation
title_short Post-Translational Modification of Proteins in Toxicological Research: Focus on Lysine Acylation
title_sort post-translational modification of proteins in toxicological research: focus on lysine acylation
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3834447/
https://www.ncbi.nlm.nih.gov/pubmed/24278632
http://dx.doi.org/10.5487/TR.2013.29.2.081
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