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Effect of DHU001, a Polyherbal Formula, on Dinitrofluorobenzene-induced Contact Dermatitis (Type I allergy)

The effect of DHU001, a mixed herbal formula consisted of 7 types aqueous extracts for various respiratory disorders were evaluated on 2,4-dinitrofluorobenzene (DNFB) -induced contact dermatitis, type I allergic model. Contact dermatitis was induced by sensitization with dinitrophenyl-derivatized ov...

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Detalles Bibliográficos
Autores principales: Lee, Hyeung-Sik, Lee, Byung-Chang, Ku, Sae-Kwang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Toxicology 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3834469/
https://www.ncbi.nlm.nih.gov/pubmed/24278515
http://dx.doi.org/10.5487/TR.2010.26.2.123
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author Lee, Hyeung-Sik
Lee, Byung-Chang
Ku, Sae-Kwang
author_facet Lee, Hyeung-Sik
Lee, Byung-Chang
Ku, Sae-Kwang
author_sort Lee, Hyeung-Sik
collection PubMed
description The effect of DHU001, a mixed herbal formula consisted of 7 types aqueous extracts for various respiratory disorders were evaluated on 2,4-dinitrofluorobenzene (DNFB) -induced contact dermatitis, type I allergic model. Contact dermatitis was induced by sensitization with dinitrophenyl-derivatized ovalbumin (DNP-OVA) and DNFB challenge as antigen. Two different dosages of DHU001 (300 and 150 mg/kg) were orally administered to DNP-OVA sensitization mice once a day for 7 days with reference material, dexamethasone (15 mg/kg, intraperitoneal treatment) . End of 7 days oral administration of DHU001 extracts or intraperitoneal treatment of dexamethasone, the changes on the edematous changes and scratching behavior were measured. Immediate after DNFB challenge on ear or paw of DNP-OVA sensitized mice, increases of ear and paw thicknesses and weights were detected with anterior ear skin (dermis to epidermis) thickness and paw scratching behavior increases. However, these contact dermatitis signs induced by DNFB treatment were reduced by treatment of the both different dosages of DHU001 and dexamethasone, respectively. The results obtained in this study suggest that oral treatment of DHU001 extracts also has relatively favorable effects on contact dermatitis.
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spelling pubmed-38344692013-11-25 Effect of DHU001, a Polyherbal Formula, on Dinitrofluorobenzene-induced Contact Dermatitis (Type I allergy) Lee, Hyeung-Sik Lee, Byung-Chang Ku, Sae-Kwang Toxicol Res Article The effect of DHU001, a mixed herbal formula consisted of 7 types aqueous extracts for various respiratory disorders were evaluated on 2,4-dinitrofluorobenzene (DNFB) -induced contact dermatitis, type I allergic model. Contact dermatitis was induced by sensitization with dinitrophenyl-derivatized ovalbumin (DNP-OVA) and DNFB challenge as antigen. Two different dosages of DHU001 (300 and 150 mg/kg) were orally administered to DNP-OVA sensitization mice once a day for 7 days with reference material, dexamethasone (15 mg/kg, intraperitoneal treatment) . End of 7 days oral administration of DHU001 extracts or intraperitoneal treatment of dexamethasone, the changes on the edematous changes and scratching behavior were measured. Immediate after DNFB challenge on ear or paw of DNP-OVA sensitized mice, increases of ear and paw thicknesses and weights were detected with anterior ear skin (dermis to epidermis) thickness and paw scratching behavior increases. However, these contact dermatitis signs induced by DNFB treatment were reduced by treatment of the both different dosages of DHU001 and dexamethasone, respectively. The results obtained in this study suggest that oral treatment of DHU001 extracts also has relatively favorable effects on contact dermatitis. The Korean Society of Toxicology 2010-06 /pmc/articles/PMC3834469/ /pubmed/24278515 http://dx.doi.org/10.5487/TR.2010.26.2.123 Text en Copyright ©2010, The Korean Society of Toxicology
spellingShingle Article
Lee, Hyeung-Sik
Lee, Byung-Chang
Ku, Sae-Kwang
Effect of DHU001, a Polyherbal Formula, on Dinitrofluorobenzene-induced Contact Dermatitis (Type I allergy)
title Effect of DHU001, a Polyherbal Formula, on Dinitrofluorobenzene-induced Contact Dermatitis (Type I allergy)
title_full Effect of DHU001, a Polyherbal Formula, on Dinitrofluorobenzene-induced Contact Dermatitis (Type I allergy)
title_fullStr Effect of DHU001, a Polyherbal Formula, on Dinitrofluorobenzene-induced Contact Dermatitis (Type I allergy)
title_full_unstemmed Effect of DHU001, a Polyherbal Formula, on Dinitrofluorobenzene-induced Contact Dermatitis (Type I allergy)
title_short Effect of DHU001, a Polyherbal Formula, on Dinitrofluorobenzene-induced Contact Dermatitis (Type I allergy)
title_sort effect of dhu001, a polyherbal formula, on dinitrofluorobenzene-induced contact dermatitis (type i allergy)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3834469/
https://www.ncbi.nlm.nih.gov/pubmed/24278515
http://dx.doi.org/10.5487/TR.2010.26.2.123
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