Antifungal Effect of Brachyglottis repanda Ethanol Extract

The crude ethanol extract of B. repanda showed the cytotoxic activity against Polio virus (25% activity at 150 μg/disk) and the minor cytotoxic activity against BSC cells (African green monkey kidney) . However, the crude ethanol extract of B. repanda was non-toxic to murine leukaemia cells CCL 46 P...

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Detalles Bibliográficos
Autores principales: Yook, Chan Nam, Na, Young Soon, Choi, Hwa Jung, You, Il Soo, Baek, Jong Min, Baek, Seung Hwa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Toxicology 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3834472/
https://www.ncbi.nlm.nih.gov/pubmed/24278514
http://dx.doi.org/10.5487/TR.2010.26.2.117
Descripción
Sumario:The crude ethanol extract of B. repanda showed the cytotoxic activity against Polio virus (25% activity at 150 μg/disk) and the minor cytotoxic activity against BSC cells (African green monkey kidney) . However, the crude ethanol extract of B. repanda was non-toxic to murine leukaemia cells CCL 46 P388D1 (IC(50), > 62,500 ng/ml) . Cytotoxic and antifungal activities were strongly shown by Fr. 64-3 which was eluted with 90% CH(3)CN/H(2)O, 100% CH(3)CN, and 50% CH(3)CN/H(2)O (SM 2 at 150 μg/disk) . The fraction 64-3 also showed the most cytotoxic activity against murine leukaemia cells (128 mg, IC(50) 10,051 ng/ml at 75 μg/disk) . These results suggest that this fraction has a potent antifungal activity against the dermatophytic fungus Trichophyton mentagrophytes ATCC 28185.

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