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Activated lymphocytes as a metabolic model for carcinogenesis
Metabolic reprogramming is a key event in tumorigenesis to support cell growth, and cancer cells frequently become both highly glycolytic and glutamine dependent. Similarly, T lymphocytes (T cells) modify their metabolism after activation by foreign antigens to shift from an energetically efficient...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3834493/ https://www.ncbi.nlm.nih.gov/pubmed/24280044 http://dx.doi.org/10.1186/2049-3002-1-5 |
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author | Macintyre, Andrew N Rathmell, Jeffrey C |
author_facet | Macintyre, Andrew N Rathmell, Jeffrey C |
author_sort | Macintyre, Andrew N |
collection | PubMed |
description | Metabolic reprogramming is a key event in tumorigenesis to support cell growth, and cancer cells frequently become both highly glycolytic and glutamine dependent. Similarly, T lymphocytes (T cells) modify their metabolism after activation by foreign antigens to shift from an energetically efficient oxidative metabolism to a highly glycolytic and glutamine-dependent metabolic program. This metabolic transition enables T cell growth, proliferation, and differentiation. In both activated T cells and cancer cells metabolic reprogramming is achieved by similar mechanisms and offers similar survival and cell growth advantages. Activated T cells thus present a useful model with which to study the development of tumor metabolism. Here, we review the metabolic similarities and distinctions between activated T cells and cancer cells, and discuss both the common signaling pathways and master metabolic regulators that lead to metabolic rewiring. Ultimately, understanding how and why T cells adopt a cancer cell-like metabolic profile may identify new therapeutic strategies to selectively target tumor metabolism or inflammatory immune responses. |
format | Online Article Text |
id | pubmed-3834493 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-38344932013-11-21 Activated lymphocytes as a metabolic model for carcinogenesis Macintyre, Andrew N Rathmell, Jeffrey C Cancer Metab Review Metabolic reprogramming is a key event in tumorigenesis to support cell growth, and cancer cells frequently become both highly glycolytic and glutamine dependent. Similarly, T lymphocytes (T cells) modify their metabolism after activation by foreign antigens to shift from an energetically efficient oxidative metabolism to a highly glycolytic and glutamine-dependent metabolic program. This metabolic transition enables T cell growth, proliferation, and differentiation. In both activated T cells and cancer cells metabolic reprogramming is achieved by similar mechanisms and offers similar survival and cell growth advantages. Activated T cells thus present a useful model with which to study the development of tumor metabolism. Here, we review the metabolic similarities and distinctions between activated T cells and cancer cells, and discuss both the common signaling pathways and master metabolic regulators that lead to metabolic rewiring. Ultimately, understanding how and why T cells adopt a cancer cell-like metabolic profile may identify new therapeutic strategies to selectively target tumor metabolism or inflammatory immune responses. BioMed Central 2013-01-23 /pmc/articles/PMC3834493/ /pubmed/24280044 http://dx.doi.org/10.1186/2049-3002-1-5 Text en Copyright © 2013 Macintyre and Rathmell; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Macintyre, Andrew N Rathmell, Jeffrey C Activated lymphocytes as a metabolic model for carcinogenesis |
title | Activated lymphocytes as a metabolic model for carcinogenesis |
title_full | Activated lymphocytes as a metabolic model for carcinogenesis |
title_fullStr | Activated lymphocytes as a metabolic model for carcinogenesis |
title_full_unstemmed | Activated lymphocytes as a metabolic model for carcinogenesis |
title_short | Activated lymphocytes as a metabolic model for carcinogenesis |
title_sort | activated lymphocytes as a metabolic model for carcinogenesis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3834493/ https://www.ncbi.nlm.nih.gov/pubmed/24280044 http://dx.doi.org/10.1186/2049-3002-1-5 |
work_keys_str_mv | AT macintyreandrewn activatedlymphocytesasametabolicmodelforcarcinogenesis AT rathmelljeffreyc activatedlymphocytesasametabolicmodelforcarcinogenesis |