High Frequency of a Single Nucleotide Substitution (c.-6-180T>G) of the Canine MDR1/ABCB1 Gene Associated with Phenobarbital-Resistant Idiopathic Epilepsy in Border Collie Dogs

A single nucleotide substitution (c.-6-180T>G) associated with resistance to phenobarbital therapy has been found in the canine MDR1/ABCB1 gene in Border Collies with idiopathic epilepsy. In the present study, a PCR-restriction fragment length polymorphism assay was developed for genotyping this...

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Detalles Bibliográficos
Autores principales: Mizukami, Keijiro, Yabuki, Akira, Chang, Hye-Sook, Uddin, Mohammad Mejbah, Rahman, Mohammad Mahbubur, Kushida, Kazuya, Kohyama, Moeko, Yamato, Osamu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3834651/
https://www.ncbi.nlm.nih.gov/pubmed/24302812
http://dx.doi.org/10.1155/2013/695918

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