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Variations in Serum Transforming Growth Factor-β1 Levels with Gender, Age and Lifestyle Factors of Healthy Japanese Adults

Elevated serum or plasma Transforming Growth Factor-β1 (TGF-β1) levels have been linked to cancer and other diseases in numerous studies; however, very few studies have reported an association between circulating TGF-β1 and lifestyle factors in healthy people. We examined the association between ser...

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Autores principales: Lin, Yingsong, Nakachi, Kei, Ito, Yoshinori, Kikuchi, Shogo, Tamakoshi, Akiko, Yagyu, Kiyoko, Watanabe, Yoshiyuki, Inaba, Yutaka, Tajima, Kazuo, JACC Study Group
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3834674/
https://www.ncbi.nlm.nih.gov/pubmed/19822955
http://dx.doi.org/10.3233/DMA-2009-0643
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author Lin, Yingsong
Nakachi, Kei
Ito, Yoshinori
Kikuchi, Shogo
Tamakoshi, Akiko
Yagyu, Kiyoko
Watanabe, Yoshiyuki
Inaba, Yutaka
Tajima, Kazuo
JACC Study Group,
author_facet Lin, Yingsong
Nakachi, Kei
Ito, Yoshinori
Kikuchi, Shogo
Tamakoshi, Akiko
Yagyu, Kiyoko
Watanabe, Yoshiyuki
Inaba, Yutaka
Tajima, Kazuo
JACC Study Group,
author_sort Lin, Yingsong
collection PubMed
description Elevated serum or plasma Transforming Growth Factor-β1 (TGF-β1) levels have been linked to cancer and other diseases in numerous studies; however, very few studies have reported an association between circulating TGF-β1 and lifestyle factors in healthy people. We examined the association between serum TGF-β1 levels and gender, age, body mass index (BMI), smoking, and drinking in a large population-based cohort study (N = 9,142). Serum TGF-β1 levels were detected by the Quantikine enzyme-linked immunoassay kit (R&D Systems). The data indicated highly significant (p<0.0001) difference in serum TGF-β1 levels between men (mean value: 37.6 ± 0.12 ng/mL, N = 4888) and women (mean value: 35.1 ± 0.12 ng/ml, N = 4254). Serum TGF-β1 levels decreased with age (trend p < 0.0001) and were positively associated with obesity (trend p < 0.0001) in both men and women. We observed a significant trend with increased serum TGF-β1 levels corresponding to increased amount of tobacco and alcohol consumption in men (trend p < 0.0001). These findings suggest that serum TGF-β1 levels appear to be modulated by gender, age and lifestyle factors such as obesity, cigarette smoking, and alcohol drinking in healthy Japanese adults.
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spelling pubmed-38346742013-12-02 Variations in Serum Transforming Growth Factor-β1 Levels with Gender, Age and Lifestyle Factors of Healthy Japanese Adults Lin, Yingsong Nakachi, Kei Ito, Yoshinori Kikuchi, Shogo Tamakoshi, Akiko Yagyu, Kiyoko Watanabe, Yoshiyuki Inaba, Yutaka Tajima, Kazuo JACC Study Group, Dis Markers Other Elevated serum or plasma Transforming Growth Factor-β1 (TGF-β1) levels have been linked to cancer and other diseases in numerous studies; however, very few studies have reported an association between circulating TGF-β1 and lifestyle factors in healthy people. We examined the association between serum TGF-β1 levels and gender, age, body mass index (BMI), smoking, and drinking in a large population-based cohort study (N = 9,142). Serum TGF-β1 levels were detected by the Quantikine enzyme-linked immunoassay kit (R&D Systems). The data indicated highly significant (p<0.0001) difference in serum TGF-β1 levels between men (mean value: 37.6 ± 0.12 ng/mL, N = 4888) and women (mean value: 35.1 ± 0.12 ng/ml, N = 4254). Serum TGF-β1 levels decreased with age (trend p < 0.0001) and were positively associated with obesity (trend p < 0.0001) in both men and women. We observed a significant trend with increased serum TGF-β1 levels corresponding to increased amount of tobacco and alcohol consumption in men (trend p < 0.0001). These findings suggest that serum TGF-β1 levels appear to be modulated by gender, age and lifestyle factors such as obesity, cigarette smoking, and alcohol drinking in healthy Japanese adults. IOS Press 2009 2009-10-12 /pmc/articles/PMC3834674/ /pubmed/19822955 http://dx.doi.org/10.3233/DMA-2009-0643 Text en Copyright © 2009 Hindawi Publishing Corporation.
spellingShingle Other
Lin, Yingsong
Nakachi, Kei
Ito, Yoshinori
Kikuchi, Shogo
Tamakoshi, Akiko
Yagyu, Kiyoko
Watanabe, Yoshiyuki
Inaba, Yutaka
Tajima, Kazuo
JACC Study Group,
Variations in Serum Transforming Growth Factor-β1 Levels with Gender, Age and Lifestyle Factors of Healthy Japanese Adults
title Variations in Serum Transforming Growth Factor-β1 Levels with Gender, Age and Lifestyle Factors of Healthy Japanese Adults
title_full Variations in Serum Transforming Growth Factor-β1 Levels with Gender, Age and Lifestyle Factors of Healthy Japanese Adults
title_fullStr Variations in Serum Transforming Growth Factor-β1 Levels with Gender, Age and Lifestyle Factors of Healthy Japanese Adults
title_full_unstemmed Variations in Serum Transforming Growth Factor-β1 Levels with Gender, Age and Lifestyle Factors of Healthy Japanese Adults
title_short Variations in Serum Transforming Growth Factor-β1 Levels with Gender, Age and Lifestyle Factors of Healthy Japanese Adults
title_sort variations in serum transforming growth factor-β1 levels with gender, age and lifestyle factors of healthy japanese adults
topic Other
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3834674/
https://www.ncbi.nlm.nih.gov/pubmed/19822955
http://dx.doi.org/10.3233/DMA-2009-0643
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