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Serum concentrations of metalloproteinase 2, metalloproteinase 9 and granzyme B in contact eczema patients

INTRODUCTION: Contact eczema is a common skin condition with complex etiology, variable clinical presentation and lengthy therapy duration. The mechanism of contact eczema is complex, since it is affected by multiple inflammatory mediators. AIM: To assess concentrations of metalloproteinase 2 (MMP-2...

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Detalles Bibliográficos
Autores principales: Wojciechowska, Milena, Żbikowska-Gotz, Magdalena, Czajkowski, Rafał, Bartuzi, Zbigniew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3834684/
https://www.ncbi.nlm.nih.gov/pubmed/24278051
http://dx.doi.org/10.5114/pdia.2013.34154
Descripción
Sumario:INTRODUCTION: Contact eczema is a common skin condition with complex etiology, variable clinical presentation and lengthy therapy duration. The mechanism of contact eczema is complex, since it is affected by multiple inflammatory mediators. AIM: To assess concentrations of metalloproteinase 2 (MMP-2), metalloproteinase 9 (MMP-9) and granzyme B (GzmB) in patients with contact eczema. MATERIAL AND METHODS: Seventy patients with contact eczema and 30 healthy persons as controls were included in the study. In all subjects, MMP-2, MMP-9 and GzmB were determined using ELISA immunoassay. In study group patients, concentrations were assayed in periods of disease exacerbation and remission. Obtained results were analyzed statistically. RESULTS: Mean MMP-2 and GzmB concentrations were found to be significantly higher in the study group than in the control group. Mean MMP-2, MMP-9 and GzmB levels were also statistically significantly higher during skin lesion relapse compared to contact eczema remission periods. CONCLUSIONS: The presented paper demonstrates that MMP-2, MMP-9 and GzmB are good markers of contact eczema exacerbations.