Knockout of an endogenous mannosyltransferase increases the homogeneity of glycoproteins produced in Pichia pastoris

The yeast Pichia pastoris is a common host for the recombinant production of biopharmaceuticals, capable of performing posttranslational modifications like glycosylation of secreted proteins. However, the activity of the OCH1 encoded α-1,6-mannosyltransferase triggers hypermannosylation of secreted...

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Detalles Bibliográficos
Autores principales: Krainer, Florian W., Gmeiner, Christoph, Neutsch, Lukas, Windwarder, Markus, Pletzenauer, Robert, Herwig, Christoph, Altmann, Friedrich, Glieder, Anton, Spadiut, Oliver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3834888/
https://www.ncbi.nlm.nih.gov/pubmed/24252857
http://dx.doi.org/10.1038/srep03279

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3834888/
https://www.ncbi.nlm.nih.gov/pubmed/24252857
http://dx.doi.org/10.1038/srep03279

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