Polyamidoamine Dendrimer Conjugates with Cyclodextrins as Novel Carriers for DNA, shRNA and siRNA

Gene, short hairpin RNA (shRNA) and small interfering RNA (siRNA) delivery can be particularly used for the treatment of diseases by the entry of genetic materials mammalian cells either to express new proteins or to suppress the expression of proteins, respectively. Polyamidoamine (PAMAM) Starburst...

Descripción completa

Detalles Bibliográficos
Autores principales: Arima, Hidetoshi, Motoyama, Keiichi, Higashi, Taishi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3834900/
https://www.ncbi.nlm.nih.gov/pubmed/24300184
http://dx.doi.org/10.3390/pharmaceutics4010130
_version_ 1782292062487445504
author Arima, Hidetoshi
Motoyama, Keiichi
Higashi, Taishi
author_facet Arima, Hidetoshi
Motoyama, Keiichi
Higashi, Taishi
author_sort Arima, Hidetoshi
collection PubMed
description Gene, short hairpin RNA (shRNA) and small interfering RNA (siRNA) delivery can be particularly used for the treatment of diseases by the entry of genetic materials mammalian cells either to express new proteins or to suppress the expression of proteins, respectively. Polyamidoamine (PAMAM) Starburst(TM) dendrimers are used as non-viral vectors (carriers) for gene, shRNA and siRNA delivery. Recently, multifunctional PAMAM dendrimers can be used for the wide range of biomedical applications including intracellular delivery of genes and nucleic acid drugs. In this context, this review paper provides the recent findings on PAMAM dendrimer conjugates with cyclodextrins (CyDs) for gene, shRNA and siRNA delivery.
format Online
Article
Text
id pubmed-3834900
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-38349002013-11-21 Polyamidoamine Dendrimer Conjugates with Cyclodextrins as Novel Carriers for DNA, shRNA and siRNA Arima, Hidetoshi Motoyama, Keiichi Higashi, Taishi Pharmaceutics Review Gene, short hairpin RNA (shRNA) and small interfering RNA (siRNA) delivery can be particularly used for the treatment of diseases by the entry of genetic materials mammalian cells either to express new proteins or to suppress the expression of proteins, respectively. Polyamidoamine (PAMAM) Starburst(TM) dendrimers are used as non-viral vectors (carriers) for gene, shRNA and siRNA delivery. Recently, multifunctional PAMAM dendrimers can be used for the wide range of biomedical applications including intracellular delivery of genes and nucleic acid drugs. In this context, this review paper provides the recent findings on PAMAM dendrimer conjugates with cyclodextrins (CyDs) for gene, shRNA and siRNA delivery. MDPI 2012-02-01 /pmc/articles/PMC3834900/ /pubmed/24300184 http://dx.doi.org/10.3390/pharmaceutics4010130 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Arima, Hidetoshi
Motoyama, Keiichi
Higashi, Taishi
Polyamidoamine Dendrimer Conjugates with Cyclodextrins as Novel Carriers for DNA, shRNA and siRNA
title Polyamidoamine Dendrimer Conjugates with Cyclodextrins as Novel Carriers for DNA, shRNA and siRNA
title_full Polyamidoamine Dendrimer Conjugates with Cyclodextrins as Novel Carriers for DNA, shRNA and siRNA
title_fullStr Polyamidoamine Dendrimer Conjugates with Cyclodextrins as Novel Carriers for DNA, shRNA and siRNA
title_full_unstemmed Polyamidoamine Dendrimer Conjugates with Cyclodextrins as Novel Carriers for DNA, shRNA and siRNA
title_short Polyamidoamine Dendrimer Conjugates with Cyclodextrins as Novel Carriers for DNA, shRNA and siRNA
title_sort polyamidoamine dendrimer conjugates with cyclodextrins as novel carriers for dna, shrna and sirna
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3834900/
https://www.ncbi.nlm.nih.gov/pubmed/24300184
http://dx.doi.org/10.3390/pharmaceutics4010130
work_keys_str_mv AT arimahidetoshi polyamidoaminedendrimerconjugateswithcyclodextrinsasnovelcarriersfordnashrnaandsirna
AT motoyamakeiichi polyamidoaminedendrimerconjugateswithcyclodextrinsasnovelcarriersfordnashrnaandsirna
AT higashitaishi polyamidoaminedendrimerconjugateswithcyclodextrinsasnovelcarriersfordnashrnaandsirna

Ejemplares similares