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Tissue Engineered Human Skin Equivalents

Human skin not only serves as an important barrier against the penetration of exogenous substances into the body, but also provides a potential avenue for the transport of functional active drugs/reagents/ingredients into the skin (topical delivery) and/or the body (transdermal delivery). In the pas...

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Detalles Bibliográficos
Autores principales: Zhang, Zheng, Michniak-Kohn, Bozena B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3834903/
https://www.ncbi.nlm.nih.gov/pubmed/24300178
http://dx.doi.org/10.3390/pharmaceutics4010026
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author Zhang, Zheng
Michniak-Kohn, Bozena B.
author_facet Zhang, Zheng
Michniak-Kohn, Bozena B.
author_sort Zhang, Zheng
collection PubMed
description Human skin not only serves as an important barrier against the penetration of exogenous substances into the body, but also provides a potential avenue for the transport of functional active drugs/reagents/ingredients into the skin (topical delivery) and/or the body (transdermal delivery). In the past three decades, research and development in human skin equivalents have advanced in parallel with those in tissue engineering and regenerative medicine. The human skin equivalents are used commercially as clinical skin substitutes and as models for permeation and toxicity screening. Several academic laboratories have developed their own human skin equivalent models and applied these models for studying skin permeation, corrosivity and irritation, compound toxicity, biochemistry, metabolism and cellular pharmacology. Various aspects of the state of the art of human skin equivalents are reviewed and discussed.
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spelling pubmed-38349032013-11-21 Tissue Engineered Human Skin Equivalents Zhang, Zheng Michniak-Kohn, Bozena B. Pharmaceutics Review Human skin not only serves as an important barrier against the penetration of exogenous substances into the body, but also provides a potential avenue for the transport of functional active drugs/reagents/ingredients into the skin (topical delivery) and/or the body (transdermal delivery). In the past three decades, research and development in human skin equivalents have advanced in parallel with those in tissue engineering and regenerative medicine. The human skin equivalents are used commercially as clinical skin substitutes and as models for permeation and toxicity screening. Several academic laboratories have developed their own human skin equivalent models and applied these models for studying skin permeation, corrosivity and irritation, compound toxicity, biochemistry, metabolism and cellular pharmacology. Various aspects of the state of the art of human skin equivalents are reviewed and discussed. MDPI 2012-01-06 /pmc/articles/PMC3834903/ /pubmed/24300178 http://dx.doi.org/10.3390/pharmaceutics4010026 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Zhang, Zheng
Michniak-Kohn, Bozena B.
Tissue Engineered Human Skin Equivalents
title Tissue Engineered Human Skin Equivalents
title_full Tissue Engineered Human Skin Equivalents
title_fullStr Tissue Engineered Human Skin Equivalents
title_full_unstemmed Tissue Engineered Human Skin Equivalents
title_short Tissue Engineered Human Skin Equivalents
title_sort tissue engineered human skin equivalents
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3834903/
https://www.ncbi.nlm.nih.gov/pubmed/24300178
http://dx.doi.org/10.3390/pharmaceutics4010026
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