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Tissue Engineered Human Skin Equivalents
Human skin not only serves as an important barrier against the penetration of exogenous substances into the body, but also provides a potential avenue for the transport of functional active drugs/reagents/ingredients into the skin (topical delivery) and/or the body (transdermal delivery). In the pas...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3834903/ https://www.ncbi.nlm.nih.gov/pubmed/24300178 http://dx.doi.org/10.3390/pharmaceutics4010026 |
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author | Zhang, Zheng Michniak-Kohn, Bozena B. |
author_facet | Zhang, Zheng Michniak-Kohn, Bozena B. |
author_sort | Zhang, Zheng |
collection | PubMed |
description | Human skin not only serves as an important barrier against the penetration of exogenous substances into the body, but also provides a potential avenue for the transport of functional active drugs/reagents/ingredients into the skin (topical delivery) and/or the body (transdermal delivery). In the past three decades, research and development in human skin equivalents have advanced in parallel with those in tissue engineering and regenerative medicine. The human skin equivalents are used commercially as clinical skin substitutes and as models for permeation and toxicity screening. Several academic laboratories have developed their own human skin equivalent models and applied these models for studying skin permeation, corrosivity and irritation, compound toxicity, biochemistry, metabolism and cellular pharmacology. Various aspects of the state of the art of human skin equivalents are reviewed and discussed. |
format | Online Article Text |
id | pubmed-3834903 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-38349032013-11-21 Tissue Engineered Human Skin Equivalents Zhang, Zheng Michniak-Kohn, Bozena B. Pharmaceutics Review Human skin not only serves as an important barrier against the penetration of exogenous substances into the body, but also provides a potential avenue for the transport of functional active drugs/reagents/ingredients into the skin (topical delivery) and/or the body (transdermal delivery). In the past three decades, research and development in human skin equivalents have advanced in parallel with those in tissue engineering and regenerative medicine. The human skin equivalents are used commercially as clinical skin substitutes and as models for permeation and toxicity screening. Several academic laboratories have developed their own human skin equivalent models and applied these models for studying skin permeation, corrosivity and irritation, compound toxicity, biochemistry, metabolism and cellular pharmacology. Various aspects of the state of the art of human skin equivalents are reviewed and discussed. MDPI 2012-01-06 /pmc/articles/PMC3834903/ /pubmed/24300178 http://dx.doi.org/10.3390/pharmaceutics4010026 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Zhang, Zheng Michniak-Kohn, Bozena B. Tissue Engineered Human Skin Equivalents |
title | Tissue Engineered Human Skin Equivalents |
title_full | Tissue Engineered Human Skin Equivalents |
title_fullStr | Tissue Engineered Human Skin Equivalents |
title_full_unstemmed | Tissue Engineered Human Skin Equivalents |
title_short | Tissue Engineered Human Skin Equivalents |
title_sort | tissue engineered human skin equivalents |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3834903/ https://www.ncbi.nlm.nih.gov/pubmed/24300178 http://dx.doi.org/10.3390/pharmaceutics4010026 |
work_keys_str_mv | AT zhangzheng tissueengineeredhumanskinequivalents AT michniakkohnbozenab tissueengineeredhumanskinequivalents |