Preclinical Absorption, Distribution, Metabolism, and Excretion of an Oral Amide Prodrug of Gemcitabine Designed to Deliver Prolonged Systemic Exposure

Gemcitabine is an intravenously administered nucleoside analog chemotherapeutic agent. The ability to deliver this agent as an oral drug would allow greater flexibility of administration and patient convenience; however, attempts have been fraught with high first-pass metabolism and potential intest...

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Detalles Bibliográficos
Autores principales: Wickremsinhe, Enaksha, Bao, Jingqi, Smith, Richard, Burton, Richard, Dow, Shannon, Perkins, Everett
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3834946/
https://www.ncbi.nlm.nih.gov/pubmed/24300450
http://dx.doi.org/10.3390/pharmaceutics5020261

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