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Polysaccharide-Based Micelles for Drug Delivery

Delivery of hydrophobic molecules and proteins has been an issue due to poor bioavailability following administration. Thus, micelle carrier systems are being investigated to improve drug solubility and stability. Due to problems with toxicity and immunogenicity, natural polysaccharides are being ex...

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Detalles Bibliográficos
Autores principales: Zhang, Nan, Wardwell, Patricia R., Bader, Rebecca A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3834947/
https://www.ncbi.nlm.nih.gov/pubmed/24300453
http://dx.doi.org/10.3390/pharmaceutics5020329
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author Zhang, Nan
Wardwell, Patricia R.
Bader, Rebecca A.
author_facet Zhang, Nan
Wardwell, Patricia R.
Bader, Rebecca A.
author_sort Zhang, Nan
collection PubMed
description Delivery of hydrophobic molecules and proteins has been an issue due to poor bioavailability following administration. Thus, micelle carrier systems are being investigated to improve drug solubility and stability. Due to problems with toxicity and immunogenicity, natural polysaccharides are being explored as substitutes for synthetic polymers in the development of new micelle systems. By grafting hydrophobic moieties to the polysaccharide backbone, self-assembled micelles can be readily formed in aqueous solution. Many polysaccharides also possess inherent bioactivity that can facilitate mucoadhesion, enhanced targeting of specific tissues, and a reduction in the inflammatory response. Furthermore, the hydrophilic nature of some polysaccharides can be exploited to enhance circulatory stability. This review will highlight the advantages of polysaccharide use in the development of drug delivery systems and will provide an overview of the polysaccharide-based micelles that have been developed to date.
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spelling pubmed-38349472013-11-21 Polysaccharide-Based Micelles for Drug Delivery Zhang, Nan Wardwell, Patricia R. Bader, Rebecca A. Pharmaceutics Review Delivery of hydrophobic molecules and proteins has been an issue due to poor bioavailability following administration. Thus, micelle carrier systems are being investigated to improve drug solubility and stability. Due to problems with toxicity and immunogenicity, natural polysaccharides are being explored as substitutes for synthetic polymers in the development of new micelle systems. By grafting hydrophobic moieties to the polysaccharide backbone, self-assembled micelles can be readily formed in aqueous solution. Many polysaccharides also possess inherent bioactivity that can facilitate mucoadhesion, enhanced targeting of specific tissues, and a reduction in the inflammatory response. Furthermore, the hydrophilic nature of some polysaccharides can be exploited to enhance circulatory stability. This review will highlight the advantages of polysaccharide use in the development of drug delivery systems and will provide an overview of the polysaccharide-based micelles that have been developed to date. MDPI 2013-05-27 /pmc/articles/PMC3834947/ /pubmed/24300453 http://dx.doi.org/10.3390/pharmaceutics5020329 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Zhang, Nan
Wardwell, Patricia R.
Bader, Rebecca A.
Polysaccharide-Based Micelles for Drug Delivery
title Polysaccharide-Based Micelles for Drug Delivery
title_full Polysaccharide-Based Micelles for Drug Delivery
title_fullStr Polysaccharide-Based Micelles for Drug Delivery
title_full_unstemmed Polysaccharide-Based Micelles for Drug Delivery
title_short Polysaccharide-Based Micelles for Drug Delivery
title_sort polysaccharide-based micelles for drug delivery
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3834947/
https://www.ncbi.nlm.nih.gov/pubmed/24300453
http://dx.doi.org/10.3390/pharmaceutics5020329
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