An improved route to 19-substituted geldanamycins as novel Hsp90 inhibitors – potential therapeutics in cancer and neurodegeneration

19-Substituted geldanamycin derivatives are efficient Hsp90 inhibitors, without the toxicity associated with the other benzoquinone ansamycins, thus giving them potential for use as molecular therapeutics in cancer and neurodegeneration. Here a new method of synthesising these important compounds is...

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Detalles Bibliográficos
Autores principales: Kitson, Russell R. A., Moody, Christopher J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2013
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835074/
https://www.ncbi.nlm.nih.gov/pubmed/23770604
http://dx.doi.org/10.1039/c3cc43457e
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author Kitson, Russell R. A.
Moody, Christopher J.
author_facet Kitson, Russell R. A.
Moody, Christopher J.
author_sort Kitson, Russell R. A.
collection PubMed
description 19-Substituted geldanamycin derivatives are efficient Hsp90 inhibitors, without the toxicity associated with the other benzoquinone ansamycins, thus giving them potential for use as molecular therapeutics in cancer and neurodegeneration. Here a new method of synthesising these important compounds is reported, eliminating the need for toxic metals and metalloids.
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spelling pubmed-38350742013-11-25 An improved route to 19-substituted geldanamycins as novel Hsp90 inhibitors – potential therapeutics in cancer and neurodegeneration Kitson, Russell R. A. Moody, Christopher J. Chem Commun (Camb) Chemistry 19-Substituted geldanamycin derivatives are efficient Hsp90 inhibitors, without the toxicity associated with the other benzoquinone ansamycins, thus giving them potential for use as molecular therapeutics in cancer and neurodegeneration. Here a new method of synthesising these important compounds is reported, eliminating the need for toxic metals and metalloids. Royal Society of Chemistry 2013-06-21 2013-06-17 /pmc/articles/PMC3835074/ /pubmed/23770604 http://dx.doi.org/10.1039/c3cc43457e Text en This journal is © The Royal Society of Chemistry 2013 http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution 3.0 Unported License (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Chemistry
Kitson, Russell R. A.
Moody, Christopher J.
An improved route to 19-substituted geldanamycins as novel Hsp90 inhibitors – potential therapeutics in cancer and neurodegeneration
title An improved route to 19-substituted geldanamycins as novel Hsp90 inhibitors – potential therapeutics in cancer and neurodegeneration
title_full An improved route to 19-substituted geldanamycins as novel Hsp90 inhibitors – potential therapeutics in cancer and neurodegeneration
title_fullStr An improved route to 19-substituted geldanamycins as novel Hsp90 inhibitors – potential therapeutics in cancer and neurodegeneration
title_full_unstemmed An improved route to 19-substituted geldanamycins as novel Hsp90 inhibitors – potential therapeutics in cancer and neurodegeneration
title_short An improved route to 19-substituted geldanamycins as novel Hsp90 inhibitors – potential therapeutics in cancer and neurodegeneration
title_sort improved route to 19-substituted geldanamycins as novel hsp90 inhibitors – potential therapeutics in cancer and neurodegeneration
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835074/
https://www.ncbi.nlm.nih.gov/pubmed/23770604
http://dx.doi.org/10.1039/c3cc43457e
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