The "Two-Faced" Effects of Reactive Oxygen Species and the Lipid Peroxidation Product 4-Hydroxynonenal in the Hallmarks of Cancer

Reacytive Oxygen Species (ROS) have long been considered to be involved in the initiation, progression and metastasis of cancer. However, accumulating evidence points to the benefical role of ROS. Moreover, ROS production, leading to apoptosis, is the mechanism by which many chemotherapeutic agents...

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Detalles Bibliográficos
Autores principales: Pizzimenti, Stefania, Toaldo, Cristina, Pettazzoni, Piergiorgio, Dianzani, Mario U., Barrera, Giuseppina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2010
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835081/
https://www.ncbi.nlm.nih.gov/pubmed/24281073
http://dx.doi.org/10.3390/cancers2020338
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author Pizzimenti, Stefania
Toaldo, Cristina
Pettazzoni, Piergiorgio
Dianzani, Mario U.
Barrera, Giuseppina
author_facet Pizzimenti, Stefania
Toaldo, Cristina
Pettazzoni, Piergiorgio
Dianzani, Mario U.
Barrera, Giuseppina
author_sort Pizzimenti, Stefania
collection PubMed
description Reacytive Oxygen Species (ROS) have long been considered to be involved in the initiation, progression and metastasis of cancer. However, accumulating evidence points to the benefical role of ROS. Moreover, ROS production, leading to apoptosis, is the mechanism by which many chemotherapeutic agents can act. Beside direct actions, ROS elicit lipid peroxidation, leading to the production of 4-hydroxynoneal (HNE). Interestingly, HNE also seems to have a dual behaviour with respect to cancer. In this review we present recent literature data which outline the "two-faced" character of oxidative stress and lipid peroxidation in carcinogenesis and in the hallmarks of cancer.
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spelling pubmed-38350812013-11-21 The "Two-Faced" Effects of Reactive Oxygen Species and the Lipid Peroxidation Product 4-Hydroxynonenal in the Hallmarks of Cancer Pizzimenti, Stefania Toaldo, Cristina Pettazzoni, Piergiorgio Dianzani, Mario U. Barrera, Giuseppina Cancers (Basel) Review Reacytive Oxygen Species (ROS) have long been considered to be involved in the initiation, progression and metastasis of cancer. However, accumulating evidence points to the benefical role of ROS. Moreover, ROS production, leading to apoptosis, is the mechanism by which many chemotherapeutic agents can act. Beside direct actions, ROS elicit lipid peroxidation, leading to the production of 4-hydroxynoneal (HNE). Interestingly, HNE also seems to have a dual behaviour with respect to cancer. In this review we present recent literature data which outline the "two-faced" character of oxidative stress and lipid peroxidation in carcinogenesis and in the hallmarks of cancer. Molecular Diversity Preservation International (MDPI) 2010-03-30 /pmc/articles/PMC3835081/ /pubmed/24281073 http://dx.doi.org/10.3390/cancers2020338 Text en © 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Pizzimenti, Stefania
Toaldo, Cristina
Pettazzoni, Piergiorgio
Dianzani, Mario U.
Barrera, Giuseppina
The "Two-Faced" Effects of Reactive Oxygen Species and the Lipid Peroxidation Product 4-Hydroxynonenal in the Hallmarks of Cancer
title The "Two-Faced" Effects of Reactive Oxygen Species and the Lipid Peroxidation Product 4-Hydroxynonenal in the Hallmarks of Cancer
title_full The "Two-Faced" Effects of Reactive Oxygen Species and the Lipid Peroxidation Product 4-Hydroxynonenal in the Hallmarks of Cancer
title_fullStr The "Two-Faced" Effects of Reactive Oxygen Species and the Lipid Peroxidation Product 4-Hydroxynonenal in the Hallmarks of Cancer
title_full_unstemmed The "Two-Faced" Effects of Reactive Oxygen Species and the Lipid Peroxidation Product 4-Hydroxynonenal in the Hallmarks of Cancer
title_short The "Two-Faced" Effects of Reactive Oxygen Species and the Lipid Peroxidation Product 4-Hydroxynonenal in the Hallmarks of Cancer
title_sort "two-faced" effects of reactive oxygen species and the lipid peroxidation product 4-hydroxynonenal in the hallmarks of cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835081/
https://www.ncbi.nlm.nih.gov/pubmed/24281073
http://dx.doi.org/10.3390/cancers2020338
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