Role of Uncoupling Proteins in Cancer

Uncoupling proteins (UCPs) are a family of inner mitochondrial membrane proteins whose function is to allow the re-entry of protons to the mitochondrial matrix, by dissipating the proton gradient and, subsequently, decreasing membrane potential and production of reactive oxygen species (ROS). Due to...

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Detalles Bibliográficos
Autores principales: Valle, Adamo, Oliver, Jordi, Roca, Pilar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2010
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835092/
https://www.ncbi.nlm.nih.gov/pubmed/24281083
http://dx.doi.org/10.3390/cancers2020567
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author Valle, Adamo
Oliver, Jordi
Roca, Pilar
author_facet Valle, Adamo
Oliver, Jordi
Roca, Pilar
author_sort Valle, Adamo
collection PubMed
description Uncoupling proteins (UCPs) are a family of inner mitochondrial membrane proteins whose function is to allow the re-entry of protons to the mitochondrial matrix, by dissipating the proton gradient and, subsequently, decreasing membrane potential and production of reactive oxygen species (ROS). Due to their pivotal role in the intersection between energy efficiency and oxidative stress, UCPs are being investigated for a potential role in cancer. In this review we compile the latest evidence showing a link between uncoupling and the carcinogenic process, paying special attention to their involvement in cancer initiation, progression and drug chemoresistance.
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spelling pubmed-38350922013-11-21 Role of Uncoupling Proteins in Cancer Valle, Adamo Oliver, Jordi Roca, Pilar Cancers (Basel) Review Uncoupling proteins (UCPs) are a family of inner mitochondrial membrane proteins whose function is to allow the re-entry of protons to the mitochondrial matrix, by dissipating the proton gradient and, subsequently, decreasing membrane potential and production of reactive oxygen species (ROS). Due to their pivotal role in the intersection between energy efficiency and oxidative stress, UCPs are being investigated for a potential role in cancer. In this review we compile the latest evidence showing a link between uncoupling and the carcinogenic process, paying special attention to their involvement in cancer initiation, progression and drug chemoresistance. Molecular Diversity Preservation International 2010-04-16 /pmc/articles/PMC3835092/ /pubmed/24281083 http://dx.doi.org/10.3390/cancers2020567 Text en © 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Valle, Adamo
Oliver, Jordi
Roca, Pilar
Role of Uncoupling Proteins in Cancer
title Role of Uncoupling Proteins in Cancer
title_full Role of Uncoupling Proteins in Cancer
title_fullStr Role of Uncoupling Proteins in Cancer
title_full_unstemmed Role of Uncoupling Proteins in Cancer
title_short Role of Uncoupling Proteins in Cancer
title_sort role of uncoupling proteins in cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835092/
https://www.ncbi.nlm.nih.gov/pubmed/24281083
http://dx.doi.org/10.3390/cancers2020567
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