A Novel Method for Sentinel Lymph Node Biopsy by Indocyanine Green Fluorescence Technique in Breast Cancer

We investigated the feasibility of sentinel lymph node (SLN) biopsy using indocyanine green (ICG) technique in 411 patients with early breast cancer at three institutes. ICG, a fluorescence source, and blue dye were injected into the subareolar area to enable real-time image-guided surgery and ident...

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Autores principales: Sugie, Tomoharu, Kassim, Kassim Abdelazeem, Takeuchi, Megumi, Hashimoto, Takashi, Yamagami, Kazuhiko, Masai, Yoshikazu, Toi, Masakazu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835100/
https://www.ncbi.nlm.nih.gov/pubmed/24281090
http://dx.doi.org/10.3390/cancers2020713
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author Sugie, Tomoharu
Kassim, Kassim Abdelazeem
Takeuchi, Megumi
Hashimoto, Takashi
Yamagami, Kazuhiko
Masai, Yoshikazu
Toi, Masakazu
author_facet Sugie, Tomoharu
Kassim, Kassim Abdelazeem
Takeuchi, Megumi
Hashimoto, Takashi
Yamagami, Kazuhiko
Masai, Yoshikazu
Toi, Masakazu
author_sort Sugie, Tomoharu
collection PubMed
description We investigated the feasibility of sentinel lymph node (SLN) biopsy using indocyanine green (ICG) technique in 411 patients with early breast cancer at three institutes. ICG, a fluorescence source, and blue dye were injected into the subareolar area to enable real-time image-guided surgery and identification of SLN fluorescence after meticulous dissection. The subcutaneous lymphatic channels were precisely detected in all cases. SLN identification rate was 99% (408/411) with a mean of 2.3 nodes identified per patient. Thirty-nine cases (9.5%) had SLNs involved and all of them were ICG positive. Thus, the ICG technique has a high SLN identification rate comparable with that of the radioisotope method.
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spelling pubmed-38351002013-11-21 A Novel Method for Sentinel Lymph Node Biopsy by Indocyanine Green Fluorescence Technique in Breast Cancer Sugie, Tomoharu Kassim, Kassim Abdelazeem Takeuchi, Megumi Hashimoto, Takashi Yamagami, Kazuhiko Masai, Yoshikazu Toi, Masakazu Cancers (Basel) Article We investigated the feasibility of sentinel lymph node (SLN) biopsy using indocyanine green (ICG) technique in 411 patients with early breast cancer at three institutes. ICG, a fluorescence source, and blue dye were injected into the subareolar area to enable real-time image-guided surgery and identification of SLN fluorescence after meticulous dissection. The subcutaneous lymphatic channels were precisely detected in all cases. SLN identification rate was 99% (408/411) with a mean of 2.3 nodes identified per patient. Thirty-nine cases (9.5%) had SLNs involved and all of them were ICG positive. Thus, the ICG technique has a high SLN identification rate comparable with that of the radioisotope method. MDPI 2010-04-27 /pmc/articles/PMC3835100/ /pubmed/24281090 http://dx.doi.org/10.3390/cancers2020713 Text en © 2010 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Sugie, Tomoharu
Kassim, Kassim Abdelazeem
Takeuchi, Megumi
Hashimoto, Takashi
Yamagami, Kazuhiko
Masai, Yoshikazu
Toi, Masakazu
A Novel Method for Sentinel Lymph Node Biopsy by Indocyanine Green Fluorescence Technique in Breast Cancer
title A Novel Method for Sentinel Lymph Node Biopsy by Indocyanine Green Fluorescence Technique in Breast Cancer
title_full A Novel Method for Sentinel Lymph Node Biopsy by Indocyanine Green Fluorescence Technique in Breast Cancer
title_fullStr A Novel Method for Sentinel Lymph Node Biopsy by Indocyanine Green Fluorescence Technique in Breast Cancer
title_full_unstemmed A Novel Method for Sentinel Lymph Node Biopsy by Indocyanine Green Fluorescence Technique in Breast Cancer
title_short A Novel Method for Sentinel Lymph Node Biopsy by Indocyanine Green Fluorescence Technique in Breast Cancer
title_sort novel method for sentinel lymph node biopsy by indocyanine green fluorescence technique in breast cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835100/
https://www.ncbi.nlm.nih.gov/pubmed/24281090
http://dx.doi.org/10.3390/cancers2020713
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