Serum Biomarkers for Early Detection of Gynecologic Cancers

Ovarian, endometrial, and cervical cancers are three of the most common malignancies of the female reproductive organs. CA 125, historically the most reliable serum marker for ovarian cancer, is elevated in 50% of early-stage ovarian tumors. For endometrial cancers, there are no established serum ma...

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Autores principales: Ueda, Yutaka, Enomoto, Takayuki, Kimura, Toshihiro, Miyatake, Takashi, Yoshino, Kiyoshi, Fujita, Masami, Kimura, Tadashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2010
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835131/
https://www.ncbi.nlm.nih.gov/pubmed/24281117
http://dx.doi.org/10.3390/cancers2021312
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author Ueda, Yutaka
Enomoto, Takayuki
Kimura, Toshihiro
Miyatake, Takashi
Yoshino, Kiyoshi
Fujita, Masami
Kimura, Tadashi
author_facet Ueda, Yutaka
Enomoto, Takayuki
Kimura, Toshihiro
Miyatake, Takashi
Yoshino, Kiyoshi
Fujita, Masami
Kimura, Tadashi
author_sort Ueda, Yutaka
collection PubMed
description Ovarian, endometrial, and cervical cancers are three of the most common malignancies of the female reproductive organs. CA 125, historically the most reliable serum marker for ovarian cancer, is elevated in 50% of early-stage ovarian tumors. For endometrial cancers, there are no established serum markers. SCC, which is the best studied serum marker for squamous cell carcinomas, has been unreliable; SCC is elevated in cervical squamous cell carcinomas ranging from 28–85% of the time. Recent proteomics-based analyses show great promise for the discovery of new and more useful biomarkers. In this review, we will discuss the currently utilized serum tumor markers for gynecologic cancers and the novel biomarkers that are now under investigation.
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spelling pubmed-38351312013-11-21 Serum Biomarkers for Early Detection of Gynecologic Cancers Ueda, Yutaka Enomoto, Takayuki Kimura, Toshihiro Miyatake, Takashi Yoshino, Kiyoshi Fujita, Masami Kimura, Tadashi Cancers (Basel) Review Ovarian, endometrial, and cervical cancers are three of the most common malignancies of the female reproductive organs. CA 125, historically the most reliable serum marker for ovarian cancer, is elevated in 50% of early-stage ovarian tumors. For endometrial cancers, there are no established serum markers. SCC, which is the best studied serum marker for squamous cell carcinomas, has been unreliable; SCC is elevated in cervical squamous cell carcinomas ranging from 28–85% of the time. Recent proteomics-based analyses show great promise for the discovery of new and more useful biomarkers. In this review, we will discuss the currently utilized serum tumor markers for gynecologic cancers and the novel biomarkers that are now under investigation. MDPI 2010-06-14 /pmc/articles/PMC3835131/ /pubmed/24281117 http://dx.doi.org/10.3390/cancers2021312 Text en © 2010 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Ueda, Yutaka
Enomoto, Takayuki
Kimura, Toshihiro
Miyatake, Takashi
Yoshino, Kiyoshi
Fujita, Masami
Kimura, Tadashi
Serum Biomarkers for Early Detection of Gynecologic Cancers
title Serum Biomarkers for Early Detection of Gynecologic Cancers
title_full Serum Biomarkers for Early Detection of Gynecologic Cancers
title_fullStr Serum Biomarkers for Early Detection of Gynecologic Cancers
title_full_unstemmed Serum Biomarkers for Early Detection of Gynecologic Cancers
title_short Serum Biomarkers for Early Detection of Gynecologic Cancers
title_sort serum biomarkers for early detection of gynecologic cancers
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835131/
https://www.ncbi.nlm.nih.gov/pubmed/24281117
http://dx.doi.org/10.3390/cancers2021312
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