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Implantable fiber-optic interface for parallel multisite long-term optical dynamic brain interrogation in freely moving mice
Seeing the big picture of functional responses within large neural networks in a freely functioning brain is crucial for understanding the cellular mechanisms behind the higher nervous activity, including the most complex brain functions, such as cognition and memory. As a breakthrough toward meetin...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835161/ https://www.ncbi.nlm.nih.gov/pubmed/24253232 http://dx.doi.org/10.1038/srep03265 |
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author | Doronina-Amitonova, L. V. Fedotov, I. V. Ivashkina, O. I. Zots, M. A. Fedotov, A. B. Anokhin, K. V. Zheltikov, A. M. |
author_facet | Doronina-Amitonova, L. V. Fedotov, I. V. Ivashkina, O. I. Zots, M. A. Fedotov, A. B. Anokhin, K. V. Zheltikov, A. M. |
author_sort | Doronina-Amitonova, L. V. |
collection | PubMed |
description | Seeing the big picture of functional responses within large neural networks in a freely functioning brain is crucial for understanding the cellular mechanisms behind the higher nervous activity, including the most complex brain functions, such as cognition and memory. As a breakthrough toward meeting this challenge, implantable fiber-optic interfaces integrating advanced optogenetic technologies and cutting-edge fiber-optic solutions have been demonstrated, enabling a long-term optogenetic manipulation of neural circuits in freely moving mice. Here, we show that a specifically designed implantable fiber-optic interface provides a powerful tool for parallel long-term optical interrogation of distinctly separate, functionally different sites in the brain of freely moving mice. This interface allows the same groups of neurons lying deeply in the brain of a freely behaving mouse to be reproducibly accessed and optically interrogated over many weeks, providing a long-term dynamic detection of genome activity in response to a broad variety of pharmacological and physiological stimuli. |
format | Online Article Text |
id | pubmed-3835161 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-38351612013-11-21 Implantable fiber-optic interface for parallel multisite long-term optical dynamic brain interrogation in freely moving mice Doronina-Amitonova, L. V. Fedotov, I. V. Ivashkina, O. I. Zots, M. A. Fedotov, A. B. Anokhin, K. V. Zheltikov, A. M. Sci Rep Article Seeing the big picture of functional responses within large neural networks in a freely functioning brain is crucial for understanding the cellular mechanisms behind the higher nervous activity, including the most complex brain functions, such as cognition and memory. As a breakthrough toward meeting this challenge, implantable fiber-optic interfaces integrating advanced optogenetic technologies and cutting-edge fiber-optic solutions have been demonstrated, enabling a long-term optogenetic manipulation of neural circuits in freely moving mice. Here, we show that a specifically designed implantable fiber-optic interface provides a powerful tool for parallel long-term optical interrogation of distinctly separate, functionally different sites in the brain of freely moving mice. This interface allows the same groups of neurons lying deeply in the brain of a freely behaving mouse to be reproducibly accessed and optically interrogated over many weeks, providing a long-term dynamic detection of genome activity in response to a broad variety of pharmacological and physiological stimuli. Nature Publishing Group 2013-11-20 /pmc/articles/PMC3835161/ /pubmed/24253232 http://dx.doi.org/10.1038/srep03265 Text en Copyright © 2013, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by-nc-nd/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/ |
spellingShingle | Article Doronina-Amitonova, L. V. Fedotov, I. V. Ivashkina, O. I. Zots, M. A. Fedotov, A. B. Anokhin, K. V. Zheltikov, A. M. Implantable fiber-optic interface for parallel multisite long-term optical dynamic brain interrogation in freely moving mice |
title | Implantable fiber-optic interface for parallel multisite long-term optical dynamic brain interrogation in freely moving mice |
title_full | Implantable fiber-optic interface for parallel multisite long-term optical dynamic brain interrogation in freely moving mice |
title_fullStr | Implantable fiber-optic interface for parallel multisite long-term optical dynamic brain interrogation in freely moving mice |
title_full_unstemmed | Implantable fiber-optic interface for parallel multisite long-term optical dynamic brain interrogation in freely moving mice |
title_short | Implantable fiber-optic interface for parallel multisite long-term optical dynamic brain interrogation in freely moving mice |
title_sort | implantable fiber-optic interface for parallel multisite long-term optical dynamic brain interrogation in freely moving mice |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835161/ https://www.ncbi.nlm.nih.gov/pubmed/24253232 http://dx.doi.org/10.1038/srep03265 |
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