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Implantable fiber-optic interface for parallel multisite long-term optical dynamic brain interrogation in freely moving mice

Seeing the big picture of functional responses within large neural networks in a freely functioning brain is crucial for understanding the cellular mechanisms behind the higher nervous activity, including the most complex brain functions, such as cognition and memory. As a breakthrough toward meetin...

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Autores principales: Doronina-Amitonova, L. V., Fedotov, I. V., Ivashkina, O. I., Zots, M. A., Fedotov, A. B., Anokhin, K. V., Zheltikov, A. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835161/
https://www.ncbi.nlm.nih.gov/pubmed/24253232
http://dx.doi.org/10.1038/srep03265
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author Doronina-Amitonova, L. V.
Fedotov, I. V.
Ivashkina, O. I.
Zots, M. A.
Fedotov, A. B.
Anokhin, K. V.
Zheltikov, A. M.
author_facet Doronina-Amitonova, L. V.
Fedotov, I. V.
Ivashkina, O. I.
Zots, M. A.
Fedotov, A. B.
Anokhin, K. V.
Zheltikov, A. M.
author_sort Doronina-Amitonova, L. V.
collection PubMed
description Seeing the big picture of functional responses within large neural networks in a freely functioning brain is crucial for understanding the cellular mechanisms behind the higher nervous activity, including the most complex brain functions, such as cognition and memory. As a breakthrough toward meeting this challenge, implantable fiber-optic interfaces integrating advanced optogenetic technologies and cutting-edge fiber-optic solutions have been demonstrated, enabling a long-term optogenetic manipulation of neural circuits in freely moving mice. Here, we show that a specifically designed implantable fiber-optic interface provides a powerful tool for parallel long-term optical interrogation of distinctly separate, functionally different sites in the brain of freely moving mice. This interface allows the same groups of neurons lying deeply in the brain of a freely behaving mouse to be reproducibly accessed and optically interrogated over many weeks, providing a long-term dynamic detection of genome activity in response to a broad variety of pharmacological and physiological stimuli.
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spelling pubmed-38351612013-11-21 Implantable fiber-optic interface for parallel multisite long-term optical dynamic brain interrogation in freely moving mice Doronina-Amitonova, L. V. Fedotov, I. V. Ivashkina, O. I. Zots, M. A. Fedotov, A. B. Anokhin, K. V. Zheltikov, A. M. Sci Rep Article Seeing the big picture of functional responses within large neural networks in a freely functioning brain is crucial for understanding the cellular mechanisms behind the higher nervous activity, including the most complex brain functions, such as cognition and memory. As a breakthrough toward meeting this challenge, implantable fiber-optic interfaces integrating advanced optogenetic technologies and cutting-edge fiber-optic solutions have been demonstrated, enabling a long-term optogenetic manipulation of neural circuits in freely moving mice. Here, we show that a specifically designed implantable fiber-optic interface provides a powerful tool for parallel long-term optical interrogation of distinctly separate, functionally different sites in the brain of freely moving mice. This interface allows the same groups of neurons lying deeply in the brain of a freely behaving mouse to be reproducibly accessed and optically interrogated over many weeks, providing a long-term dynamic detection of genome activity in response to a broad variety of pharmacological and physiological stimuli. Nature Publishing Group 2013-11-20 /pmc/articles/PMC3835161/ /pubmed/24253232 http://dx.doi.org/10.1038/srep03265 Text en Copyright © 2013, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by-nc-nd/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/
spellingShingle Article
Doronina-Amitonova, L. V.
Fedotov, I. V.
Ivashkina, O. I.
Zots, M. A.
Fedotov, A. B.
Anokhin, K. V.
Zheltikov, A. M.
Implantable fiber-optic interface for parallel multisite long-term optical dynamic brain interrogation in freely moving mice
title Implantable fiber-optic interface for parallel multisite long-term optical dynamic brain interrogation in freely moving mice
title_full Implantable fiber-optic interface for parallel multisite long-term optical dynamic brain interrogation in freely moving mice
title_fullStr Implantable fiber-optic interface for parallel multisite long-term optical dynamic brain interrogation in freely moving mice
title_full_unstemmed Implantable fiber-optic interface for parallel multisite long-term optical dynamic brain interrogation in freely moving mice
title_short Implantable fiber-optic interface for parallel multisite long-term optical dynamic brain interrogation in freely moving mice
title_sort implantable fiber-optic interface for parallel multisite long-term optical dynamic brain interrogation in freely moving mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835161/
https://www.ncbi.nlm.nih.gov/pubmed/24253232
http://dx.doi.org/10.1038/srep03265
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