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The Essential Role of DOCK8 in Humoral Immunity

The processes that normally generate and maintain adaptive immunity and immunological memory are poorly understood, and yet of fundamental importance when infectious diseases place such a major economic and social burden on the world's health and agriculture systems. Defects in these mechanisms...

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Detalles Bibliográficos
Autores principales: Randall, Katrina L., Lambe, Teresa, Goodnow, Chris C., Cornall, Richard J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835290/
https://www.ncbi.nlm.nih.gov/pubmed/21178273
http://dx.doi.org/10.3233/DMA-2010-0739
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author Randall, Katrina L.
Lambe, Teresa
Goodnow, Chris C.
Cornall, Richard J.
author_facet Randall, Katrina L.
Lambe, Teresa
Goodnow, Chris C.
Cornall, Richard J.
author_sort Randall, Katrina L.
collection PubMed
description The processes that normally generate and maintain adaptive immunity and immunological memory are poorly understood, and yet of fundamental importance when infectious diseases place such a major economic and social burden on the world's health and agriculture systems. Defects in these mechanisms also underlie the many forms of human primary immunodeficiency. Identifying these mechanisms in a systematic way is therefore important if we are to develop better strategies for treating and preventing infection, inherited disease, transplant rejection and autoimmunity. In this review we describe a genome-wide screen in mice for the genes important for generating these adaptive responses, and describe two independent DOCK8 mutant mice strains identified by this screen. DOCK 8 was found to play an essential role in humoral immune responses and to be important in the proper formation of the B cell immunological synapse.
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spelling pubmed-38352902013-12-10 The Essential Role of DOCK8 in Humoral Immunity Randall, Katrina L. Lambe, Teresa Goodnow, Chris C. Cornall, Richard J. Dis Markers Other The processes that normally generate and maintain adaptive immunity and immunological memory are poorly understood, and yet of fundamental importance when infectious diseases place such a major economic and social burden on the world's health and agriculture systems. Defects in these mechanisms also underlie the many forms of human primary immunodeficiency. Identifying these mechanisms in a systematic way is therefore important if we are to develop better strategies for treating and preventing infection, inherited disease, transplant rejection and autoimmunity. In this review we describe a genome-wide screen in mice for the genes important for generating these adaptive responses, and describe two independent DOCK8 mutant mice strains identified by this screen. DOCK 8 was found to play an essential role in humoral immune responses and to be important in the proper formation of the B cell immunological synapse. IOS Press 2010 2010-12-20 /pmc/articles/PMC3835290/ /pubmed/21178273 http://dx.doi.org/10.3233/DMA-2010-0739 Text en Copyright © 2010 Hindawi Publishing Corporation.
spellingShingle Other
Randall, Katrina L.
Lambe, Teresa
Goodnow, Chris C.
Cornall, Richard J.
The Essential Role of DOCK8 in Humoral Immunity
title The Essential Role of DOCK8 in Humoral Immunity
title_full The Essential Role of DOCK8 in Humoral Immunity
title_fullStr The Essential Role of DOCK8 in Humoral Immunity
title_full_unstemmed The Essential Role of DOCK8 in Humoral Immunity
title_short The Essential Role of DOCK8 in Humoral Immunity
title_sort essential role of dock8 in humoral immunity
topic Other
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835290/
https://www.ncbi.nlm.nih.gov/pubmed/21178273
http://dx.doi.org/10.3233/DMA-2010-0739
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