Double Translocation: An Interesting Family History

Double balanced translocations are particularly rare and the risk of a fetus with an unbalanced chromosomal anomaly is greater than for single translocation carriers. In this present case, we describe an interesting family history which included three generations. A couple, married for 4 years, was...

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Detalles Bibliográficos
Autores principales: Uysal, A, Uludağ, A, Sılan, F, Erçelen, N, Zafer, C, Özdemir, Ö
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Macedonian Science of Sciences and Arts 201
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835301/
https://www.ncbi.nlm.nih.gov/pubmed/24265590
http://dx.doi.org/ 10.2478/bjmg-2013-0022
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author Uysal, A
Uludağ, A
Sılan, F
Erçelen, N
Zafer, C
Özdemir, Ö
author_facet Uysal, A
Uludağ, A
Sılan, F
Erçelen, N
Zafer, C
Özdemir, Ö
author_sort Uysal, A
collection PubMed
description Double balanced translocations are particularly rare and the risk of a fetus with an unbalanced chromosomal anomaly is greater than for single translocation carriers. In this present case, we describe an interesting family history which included three generations. A couple, married for 4 years, was referred to the genetic clinic due to infertility and family chromosome anomalies. A GTG-band chromosome analysis indicated that the male partner’s karyotype was 45,XY, t(3;18)(q11;ptel)t(13;14)(q10;q10). The same double balanced translocation was found in two others family members.
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spelling pubmed-38353012013-11-21 Double Translocation: An Interesting Family History Uysal, A Uludağ, A Sılan, F Erçelen, N Zafer, C Özdemir, Ö Balkan J Med Genet Case Report Double balanced translocations are particularly rare and the risk of a fetus with an unbalanced chromosomal anomaly is greater than for single translocation carriers. In this present case, we describe an interesting family history which included three generations. A couple, married for 4 years, was referred to the genetic clinic due to infertility and family chromosome anomalies. A GTG-band chromosome analysis indicated that the male partner’s karyotype was 45,XY, t(3;18)(q11;ptel)t(13;14)(q10;q10). The same double balanced translocation was found in two others family members. Macedonian Science of Sciences and Arts 2013 -06 2013 -10- 03 /pmc/articles/PMC3835301/ /pubmed/24265590 http://dx.doi.org/ 10.2478/bjmg-2013-0022 Text en © Macedonian Academy of Sciences and Arts This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivs license (http://creativecommons.org/licenses/by-nc-nd/3.0/), which means that the text may be used for non-commercial purposes, provided credit is given to the author.
spellingShingle Case Report
Uysal, A
Uludağ, A
Sılan, F
Erçelen, N
Zafer, C
Özdemir, Ö
Double Translocation: An Interesting Family History
title Double Translocation: An Interesting Family History
title_full Double Translocation: An Interesting Family History
title_fullStr Double Translocation: An Interesting Family History
title_full_unstemmed Double Translocation: An Interesting Family History
title_short Double Translocation: An Interesting Family History
title_sort double translocation: an interesting family history
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835301/
https://www.ncbi.nlm.nih.gov/pubmed/24265590
http://dx.doi.org/ 10.2478/bjmg-2013-0022
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AT ozdemiro doubletranslocationaninterestingfamilyhistory

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