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Reducing cannabinoid abuse and preventing relapse by enhancing endogenous brain levels of kynurenic acid

In the reward circuitry of the brain, alpha-7-nicotinic acetylcholine receptors (α7nAChRs) modulate effects of delta-9-tetrahydrocannabinol (THC), marijuana’s main psychoactive ingredient. Kynurenic acid (KYNA) is an endogenous negative allosteric modulator of α7nAChRs. Here we report that the kynur...

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Detalles Bibliográficos
Autores principales:	Justinova, Zuzana, Mascia, Paola, Wu, Hui-Qiu, Secci, Maria E., Redhi, Godfrey H., Panlilio, Leigh V., Scherma, Maria, Barnes, Chanel, Parashos, Alexandra, Zara, Tamara, Fratta, Walter, Solinas, Marcello, Pistis, Marco, Bergman, Jack, Kangas, Brian D., Ferré, Sergi, Tanda, Gianluigi, Schwarcz, Robert, Goldberg, Steven R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835353/ https://www.ncbi.nlm.nih.gov/pubmed/24121737 http://dx.doi.org/10.1038/nn.3540

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