Cargando…
Emergent Biomarkers of Residual Cardiovascular Risk in Patients with Low HDL-c and/or High Triglycerides and Average LDL-c Concentrations: Focus on HDL Subpopulations, Oxidized LDL, Adiponectin, and Uric Acid
This study intended to determine the impact of HDL-c and/or TGs levels on patients with average LDL-c concentration, focusing on lipidic, oxidative, inflammatory, and angiogenic profiles. Patients with cardiovascular risk factors (n = 169) were divided into 4 subgroups, combining normal and low HDL-...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835367/ https://www.ncbi.nlm.nih.gov/pubmed/24319364 http://dx.doi.org/10.1155/2013/387849 |
_version_ | 1782292145602822144 |
---|---|
author | Mascarenhas-Melo, Filipa Palavra, Filipe Marado, Daniela Sereno, José Teixeira-Lemos, Edite Freitas, Isabel Isabel-Mendonça, Maria Pinto, Rui Teixeira, Frederico Reis, Flávio |
author_facet | Mascarenhas-Melo, Filipa Palavra, Filipe Marado, Daniela Sereno, José Teixeira-Lemos, Edite Freitas, Isabel Isabel-Mendonça, Maria Pinto, Rui Teixeira, Frederico Reis, Flávio |
author_sort | Mascarenhas-Melo, Filipa |
collection | PubMed |
description | This study intended to determine the impact of HDL-c and/or TGs levels on patients with average LDL-c concentration, focusing on lipidic, oxidative, inflammatory, and angiogenic profiles. Patients with cardiovascular risk factors (n = 169) were divided into 4 subgroups, combining normal and low HDL-c with normal and high TGs patients. The following data was analyzed: BP, BMI, waist circumference and serum glucose, Total-c, TGs, LDL-c, oxidized-LDL, total HDL-c and HDL subpopulations, paraoxonase-1 (PON1) activity, hsCRP, uric acid, TNF-α, adiponectin, VEGF, and iCAM1. The two populations with increased TGs levels, regardless of the normal or low HDL-c, presented obesity and higher waist circumference, Total-c, LDL-c, Ox-LDL, and uric acid. Adiponectin concentration was significantly lower and VEGF was higher in the population with cumulative low values of HDL-c and high values of TGs, while HDL quality was reduced in the populations with impaired values of HDL-c and/or TGs, viewed by reduced large and increased small HDL subfractions. In conclusion, in a population with cardiovascular risk factors, low HDL-c and/or high TGs concentrations seem to be associated with a poor cardiometabolic profile, despite average LDL-c levels. This condition, often called residual risk, is better evidenced by using both traditional and nontraditional CV biomarkers, including large and small HDL subfractions, Ox-LDL, adiponectin, VEGF, and uric acid. |
format | Online Article Text |
id | pubmed-3835367 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-38353672013-12-08 Emergent Biomarkers of Residual Cardiovascular Risk in Patients with Low HDL-c and/or High Triglycerides and Average LDL-c Concentrations: Focus on HDL Subpopulations, Oxidized LDL, Adiponectin, and Uric Acid Mascarenhas-Melo, Filipa Palavra, Filipe Marado, Daniela Sereno, José Teixeira-Lemos, Edite Freitas, Isabel Isabel-Mendonça, Maria Pinto, Rui Teixeira, Frederico Reis, Flávio ScientificWorldJournal Research Article This study intended to determine the impact of HDL-c and/or TGs levels on patients with average LDL-c concentration, focusing on lipidic, oxidative, inflammatory, and angiogenic profiles. Patients with cardiovascular risk factors (n = 169) were divided into 4 subgroups, combining normal and low HDL-c with normal and high TGs patients. The following data was analyzed: BP, BMI, waist circumference and serum glucose, Total-c, TGs, LDL-c, oxidized-LDL, total HDL-c and HDL subpopulations, paraoxonase-1 (PON1) activity, hsCRP, uric acid, TNF-α, adiponectin, VEGF, and iCAM1. The two populations with increased TGs levels, regardless of the normal or low HDL-c, presented obesity and higher waist circumference, Total-c, LDL-c, Ox-LDL, and uric acid. Adiponectin concentration was significantly lower and VEGF was higher in the population with cumulative low values of HDL-c and high values of TGs, while HDL quality was reduced in the populations with impaired values of HDL-c and/or TGs, viewed by reduced large and increased small HDL subfractions. In conclusion, in a population with cardiovascular risk factors, low HDL-c and/or high TGs concentrations seem to be associated with a poor cardiometabolic profile, despite average LDL-c levels. This condition, often called residual risk, is better evidenced by using both traditional and nontraditional CV biomarkers, including large and small HDL subfractions, Ox-LDL, adiponectin, VEGF, and uric acid. Hindawi Publishing Corporation 2013-11-04 /pmc/articles/PMC3835367/ /pubmed/24319364 http://dx.doi.org/10.1155/2013/387849 Text en Copyright © 2013 Filipa Mascarenhas-Melo et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Mascarenhas-Melo, Filipa Palavra, Filipe Marado, Daniela Sereno, José Teixeira-Lemos, Edite Freitas, Isabel Isabel-Mendonça, Maria Pinto, Rui Teixeira, Frederico Reis, Flávio Emergent Biomarkers of Residual Cardiovascular Risk in Patients with Low HDL-c and/or High Triglycerides and Average LDL-c Concentrations: Focus on HDL Subpopulations, Oxidized LDL, Adiponectin, and Uric Acid |
title | Emergent Biomarkers of Residual Cardiovascular Risk in Patients with Low HDL-c and/or High Triglycerides and Average LDL-c Concentrations: Focus on HDL Subpopulations, Oxidized LDL, Adiponectin, and Uric Acid |
title_full | Emergent Biomarkers of Residual Cardiovascular Risk in Patients with Low HDL-c and/or High Triglycerides and Average LDL-c Concentrations: Focus on HDL Subpopulations, Oxidized LDL, Adiponectin, and Uric Acid |
title_fullStr | Emergent Biomarkers of Residual Cardiovascular Risk in Patients with Low HDL-c and/or High Triglycerides and Average LDL-c Concentrations: Focus on HDL Subpopulations, Oxidized LDL, Adiponectin, and Uric Acid |
title_full_unstemmed | Emergent Biomarkers of Residual Cardiovascular Risk in Patients with Low HDL-c and/or High Triglycerides and Average LDL-c Concentrations: Focus on HDL Subpopulations, Oxidized LDL, Adiponectin, and Uric Acid |
title_short | Emergent Biomarkers of Residual Cardiovascular Risk in Patients with Low HDL-c and/or High Triglycerides and Average LDL-c Concentrations: Focus on HDL Subpopulations, Oxidized LDL, Adiponectin, and Uric Acid |
title_sort | emergent biomarkers of residual cardiovascular risk in patients with low hdl-c and/or high triglycerides and average ldl-c concentrations: focus on hdl subpopulations, oxidized ldl, adiponectin, and uric acid |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835367/ https://www.ncbi.nlm.nih.gov/pubmed/24319364 http://dx.doi.org/10.1155/2013/387849 |
work_keys_str_mv | AT mascarenhasmelofilipa emergentbiomarkersofresidualcardiovascularriskinpatientswithlowhdlcandorhightriglyceridesandaverageldlcconcentrationsfocusonhdlsubpopulationsoxidizedldladiponectinanduricacid AT palavrafilipe emergentbiomarkersofresidualcardiovascularriskinpatientswithlowhdlcandorhightriglyceridesandaverageldlcconcentrationsfocusonhdlsubpopulationsoxidizedldladiponectinanduricacid AT maradodaniela emergentbiomarkersofresidualcardiovascularriskinpatientswithlowhdlcandorhightriglyceridesandaverageldlcconcentrationsfocusonhdlsubpopulationsoxidizedldladiponectinanduricacid AT serenojose emergentbiomarkersofresidualcardiovascularriskinpatientswithlowhdlcandorhightriglyceridesandaverageldlcconcentrationsfocusonhdlsubpopulationsoxidizedldladiponectinanduricacid AT teixeiralemosedite emergentbiomarkersofresidualcardiovascularriskinpatientswithlowhdlcandorhightriglyceridesandaverageldlcconcentrationsfocusonhdlsubpopulationsoxidizedldladiponectinanduricacid AT freitasisabel emergentbiomarkersofresidualcardiovascularriskinpatientswithlowhdlcandorhightriglyceridesandaverageldlcconcentrationsfocusonhdlsubpopulationsoxidizedldladiponectinanduricacid AT isabelmendoncamaria emergentbiomarkersofresidualcardiovascularriskinpatientswithlowhdlcandorhightriglyceridesandaverageldlcconcentrationsfocusonhdlsubpopulationsoxidizedldladiponectinanduricacid AT pintorui emergentbiomarkersofresidualcardiovascularriskinpatientswithlowhdlcandorhightriglyceridesandaverageldlcconcentrationsfocusonhdlsubpopulationsoxidizedldladiponectinanduricacid AT teixeirafrederico emergentbiomarkersofresidualcardiovascularriskinpatientswithlowhdlcandorhightriglyceridesandaverageldlcconcentrationsfocusonhdlsubpopulationsoxidizedldladiponectinanduricacid AT reisflavio emergentbiomarkersofresidualcardiovascularriskinpatientswithlowhdlcandorhightriglyceridesandaverageldlcconcentrationsfocusonhdlsubpopulationsoxidizedldladiponectinanduricacid |