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Irisin, Two Years Later
In January 2012, Boström and colleagues identified a new muscle tissue secreted peptide, which they named irisin, to highlight its role as a messenger that comes from skeletal muscle to other parts of the body. Irisin is a cleaved and secreted fragment of FNDC5 (also known as FRCP2 and PeP), a membe...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835481/ https://www.ncbi.nlm.nih.gov/pubmed/24298283 http://dx.doi.org/10.1155/2013/746281 |
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author | Novelle, Marta G. Contreras, Cristina Romero-Picó, Amparo López, Miguel Diéguez, Carlos |
author_facet | Novelle, Marta G. Contreras, Cristina Romero-Picó, Amparo López, Miguel Diéguez, Carlos |
author_sort | Novelle, Marta G. |
collection | PubMed |
description | In January 2012, Boström and colleagues identified a new muscle tissue secreted peptide, which they named irisin, to highlight its role as a messenger that comes from skeletal muscle to other parts of the body. Irisin is a cleaved and secreted fragment of FNDC5 (also known as FRCP2 and PeP), a member of fibronectin type III repeat containing gene family. Major interest in this protein arose because of its great therapeutic potential in diabetes and perhaps also therapy for obesity. Here we review the most important aspects of irisin's action and discuss its involvement in energy and metabolic homeostasis and whether the beneficial effects of exercise in these disease states could be mediated by this protein. In addition the effects of irisin at the central nervous system (CNS) are highlighted. It is concluded that although current and upcoming research on irisin is very promising it is still necessary to deepen in several aspects in order to clarify its full potential as a meaningful drug target in human disease states. |
format | Online Article Text |
id | pubmed-3835481 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-38354812013-12-02 Irisin, Two Years Later Novelle, Marta G. Contreras, Cristina Romero-Picó, Amparo López, Miguel Diéguez, Carlos Int J Endocrinol Review Article In January 2012, Boström and colleagues identified a new muscle tissue secreted peptide, which they named irisin, to highlight its role as a messenger that comes from skeletal muscle to other parts of the body. Irisin is a cleaved and secreted fragment of FNDC5 (also known as FRCP2 and PeP), a member of fibronectin type III repeat containing gene family. Major interest in this protein arose because of its great therapeutic potential in diabetes and perhaps also therapy for obesity. Here we review the most important aspects of irisin's action and discuss its involvement in energy and metabolic homeostasis and whether the beneficial effects of exercise in these disease states could be mediated by this protein. In addition the effects of irisin at the central nervous system (CNS) are highlighted. It is concluded that although current and upcoming research on irisin is very promising it is still necessary to deepen in several aspects in order to clarify its full potential as a meaningful drug target in human disease states. Hindawi Publishing Corporation 2013 2013-11-05 /pmc/articles/PMC3835481/ /pubmed/24298283 http://dx.doi.org/10.1155/2013/746281 Text en Copyright © 2013 Marta G. Novelle et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Novelle, Marta G. Contreras, Cristina Romero-Picó, Amparo López, Miguel Diéguez, Carlos Irisin, Two Years Later |
title | Irisin, Two Years Later |
title_full | Irisin, Two Years Later |
title_fullStr | Irisin, Two Years Later |
title_full_unstemmed | Irisin, Two Years Later |
title_short | Irisin, Two Years Later |
title_sort | irisin, two years later |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835481/ https://www.ncbi.nlm.nih.gov/pubmed/24298283 http://dx.doi.org/10.1155/2013/746281 |
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