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Korean Guideline for Iron Chelation Therapy in Transfusion-Induced Iron Overload

Many Korean patients with transfusion-induced iron overload experience serious clinical sequelae, including organ damage, and require lifelong chelation therapy. However, due to a lack of compliance and/or unavailability of an appropriate chelator, most patients have not been treated effectively. De...

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Autores principales: Jang, Jun Ho, Lee, Je-Hwan, Yoon, Sung-Soo, Jo, Deog-Yeon, Kim, Hyeoung-Joon, Chung, Jooseop, Lee, Jong Wook
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Academy of Medical Sciences 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835496/
https://www.ncbi.nlm.nih.gov/pubmed/24265517
http://dx.doi.org/10.3346/jkms.2013.28.11.1563
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author Jang, Jun Ho
Lee, Je-Hwan
Yoon, Sung-Soo
Jo, Deog-Yeon
Kim, Hyeoung-Joon
Chung, Jooseop
Lee, Jong Wook
author_facet Jang, Jun Ho
Lee, Je-Hwan
Yoon, Sung-Soo
Jo, Deog-Yeon
Kim, Hyeoung-Joon
Chung, Jooseop
Lee, Jong Wook
author_sort Jang, Jun Ho
collection PubMed
description Many Korean patients with transfusion-induced iron overload experience serious clinical sequelae, including organ damage, and require lifelong chelation therapy. However, due to a lack of compliance and/or unavailability of an appropriate chelator, most patients have not been treated effectively. Deferasirox (DFX), a once-daily oral iron chelator for both adult and pediatric patients with transfusion-induced iron overload, is now available in Korea. The effectiveness of deferasirox in reducing or maintaining body iron has been demonstrated in many studies of patients with a variety of transfusion-induced anemias such as myelodysplastic syndromes, aplastic anemia, and other chronic anemias. The recommended initial daily dose of DFX is 20 mg/kg body weight, taken on an empty stomach at least 30 min before food and serum ferritin levels should be maintained below 1000 ng/mL. To optimize the management of transfusion-induced iron overload, the Korean Society of Hematology Aplastic Anemia Working Party (KSHAAWP) reviewed the general consensus on iron overload and the Korean data on the clinical benefits of iron chelation therapy, and developed a Korean guideline for the treatment of iron overload.
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spelling pubmed-38354962013-11-21 Korean Guideline for Iron Chelation Therapy in Transfusion-Induced Iron Overload Jang, Jun Ho Lee, Je-Hwan Yoon, Sung-Soo Jo, Deog-Yeon Kim, Hyeoung-Joon Chung, Jooseop Lee, Jong Wook J Korean Med Sci Special Article Many Korean patients with transfusion-induced iron overload experience serious clinical sequelae, including organ damage, and require lifelong chelation therapy. However, due to a lack of compliance and/or unavailability of an appropriate chelator, most patients have not been treated effectively. Deferasirox (DFX), a once-daily oral iron chelator for both adult and pediatric patients with transfusion-induced iron overload, is now available in Korea. The effectiveness of deferasirox in reducing or maintaining body iron has been demonstrated in many studies of patients with a variety of transfusion-induced anemias such as myelodysplastic syndromes, aplastic anemia, and other chronic anemias. The recommended initial daily dose of DFX is 20 mg/kg body weight, taken on an empty stomach at least 30 min before food and serum ferritin levels should be maintained below 1000 ng/mL. To optimize the management of transfusion-induced iron overload, the Korean Society of Hematology Aplastic Anemia Working Party (KSHAAWP) reviewed the general consensus on iron overload and the Korean data on the clinical benefits of iron chelation therapy, and developed a Korean guideline for the treatment of iron overload. The Korean Academy of Medical Sciences 2013-11 2013-10-31 /pmc/articles/PMC3835496/ /pubmed/24265517 http://dx.doi.org/10.3346/jkms.2013.28.11.1563 Text en © 2013 The Korean Academy of Medical Sciences. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Special Article
Jang, Jun Ho
Lee, Je-Hwan
Yoon, Sung-Soo
Jo, Deog-Yeon
Kim, Hyeoung-Joon
Chung, Jooseop
Lee, Jong Wook
Korean Guideline for Iron Chelation Therapy in Transfusion-Induced Iron Overload
title Korean Guideline for Iron Chelation Therapy in Transfusion-Induced Iron Overload
title_full Korean Guideline for Iron Chelation Therapy in Transfusion-Induced Iron Overload
title_fullStr Korean Guideline for Iron Chelation Therapy in Transfusion-Induced Iron Overload
title_full_unstemmed Korean Guideline for Iron Chelation Therapy in Transfusion-Induced Iron Overload
title_short Korean Guideline for Iron Chelation Therapy in Transfusion-Induced Iron Overload
title_sort korean guideline for iron chelation therapy in transfusion-induced iron overload
topic Special Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835496/
https://www.ncbi.nlm.nih.gov/pubmed/24265517
http://dx.doi.org/10.3346/jkms.2013.28.11.1563
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