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Comparison of Specific IgE Antibodies to Wheat Component Allergens in Two Phenotypes of Wheat Allergy

Specific IgE to gliadin was proposed as a marker for wheat dependent exercise induced anaphylaxis, while Tri a 14 was found to induce IgE response in baker's asthma. We evaluated whether these components could be used for discriminating phenotypes of wheat allergy. Twenty-nine patients who were...

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Autores principales: Nam, Young-Hee, Hwang, Eui-Kyung, Jin, Hyun Jung, Lee, Jeong Min, Shin, Yoo-Seob, Ye, Young-Min, Palacin, Arantxa, Salcedo, Gabriel, Lee, Soo-Young, Park, Hae-Sim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Academy of Medical Sciences 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835518/
https://www.ncbi.nlm.nih.gov/pubmed/24265539
http://dx.doi.org/10.3346/jkms.2013.28.11.1697
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author Nam, Young-Hee
Hwang, Eui-Kyung
Jin, Hyun Jung
Lee, Jeong Min
Shin, Yoo-Seob
Ye, Young-Min
Palacin, Arantxa
Salcedo, Gabriel
Lee, Soo-Young
Park, Hae-Sim
author_facet Nam, Young-Hee
Hwang, Eui-Kyung
Jin, Hyun Jung
Lee, Jeong Min
Shin, Yoo-Seob
Ye, Young-Min
Palacin, Arantxa
Salcedo, Gabriel
Lee, Soo-Young
Park, Hae-Sim
author_sort Nam, Young-Hee
collection PubMed
description Specific IgE to gliadin was proposed as a marker for wheat dependent exercise induced anaphylaxis, while Tri a 14 was found to induce IgE response in baker's asthma. We evaluated whether these components could be used for discriminating phenotypes of wheat allergy. Twenty-nine patients who were wheat-induced anaphylaxis and/or urticaria (n=21, group I) and baker's asthma (n=8, group II) were enrolled. The prevalence of serum specific IgE to Tri a 14 was higher in group II (25%) than in group I (4.8%), while the serum specific IgE to gliadin was significantly higher in group I (70%) than in group II (12.5%). The cutoff value for predicting the baker's asthma using the ratio of serum specific IgE to Tri a 14 to gliadin was 742.8 optical density×1,000/(kU/L) with high sensitivity and specificity. These findings suggest that Tri a 14/gliadin may be a potential marker for predicting baker's asthma.
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spelling pubmed-38355182013-11-21 Comparison of Specific IgE Antibodies to Wheat Component Allergens in Two Phenotypes of Wheat Allergy Nam, Young-Hee Hwang, Eui-Kyung Jin, Hyun Jung Lee, Jeong Min Shin, Yoo-Seob Ye, Young-Min Palacin, Arantxa Salcedo, Gabriel Lee, Soo-Young Park, Hae-Sim J Korean Med Sci Brief Communication Specific IgE to gliadin was proposed as a marker for wheat dependent exercise induced anaphylaxis, while Tri a 14 was found to induce IgE response in baker's asthma. We evaluated whether these components could be used for discriminating phenotypes of wheat allergy. Twenty-nine patients who were wheat-induced anaphylaxis and/or urticaria (n=21, group I) and baker's asthma (n=8, group II) were enrolled. The prevalence of serum specific IgE to Tri a 14 was higher in group II (25%) than in group I (4.8%), while the serum specific IgE to gliadin was significantly higher in group I (70%) than in group II (12.5%). The cutoff value for predicting the baker's asthma using the ratio of serum specific IgE to Tri a 14 to gliadin was 742.8 optical density×1,000/(kU/L) with high sensitivity and specificity. These findings suggest that Tri a 14/gliadin may be a potential marker for predicting baker's asthma. The Korean Academy of Medical Sciences 2013-11 2013-10-31 /pmc/articles/PMC3835518/ /pubmed/24265539 http://dx.doi.org/10.3346/jkms.2013.28.11.1697 Text en © 2013 The Korean Academy of Medical Sciences. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Communication
Nam, Young-Hee
Hwang, Eui-Kyung
Jin, Hyun Jung
Lee, Jeong Min
Shin, Yoo-Seob
Ye, Young-Min
Palacin, Arantxa
Salcedo, Gabriel
Lee, Soo-Young
Park, Hae-Sim
Comparison of Specific IgE Antibodies to Wheat Component Allergens in Two Phenotypes of Wheat Allergy
title Comparison of Specific IgE Antibodies to Wheat Component Allergens in Two Phenotypes of Wheat Allergy
title_full Comparison of Specific IgE Antibodies to Wheat Component Allergens in Two Phenotypes of Wheat Allergy
title_fullStr Comparison of Specific IgE Antibodies to Wheat Component Allergens in Two Phenotypes of Wheat Allergy
title_full_unstemmed Comparison of Specific IgE Antibodies to Wheat Component Allergens in Two Phenotypes of Wheat Allergy
title_short Comparison of Specific IgE Antibodies to Wheat Component Allergens in Two Phenotypes of Wheat Allergy
title_sort comparison of specific ige antibodies to wheat component allergens in two phenotypes of wheat allergy
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835518/
https://www.ncbi.nlm.nih.gov/pubmed/24265539
http://dx.doi.org/10.3346/jkms.2013.28.11.1697
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