Cargando…
Bladder Cancer Risk Associated with Genotypic Polymorphism of the Matrix Metalloproteinase-1 and 7 in North Indian Population
Matrix metalloproteinases (MMPs) contribute to tumor invasion and microenvironment, hence are associated with bladder cancer risk. We therefore, tested whether polymorphisms in MMP genes modify the risk of bladder cancer (BC) and whether smoke exposure modifies this risk. Genotyping was performed in...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
IOS Press
2010
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835524/ https://www.ncbi.nlm.nih.gov/pubmed/20826916 http://dx.doi.org/10.3233/DMA-2010-0724 |
_version_ | 1782292170428907520 |
---|---|
author | Srivastava, Priyanka Gangwar, Ruchika Kapoor, Rakesh Mittal, Rama D. |
author_facet | Srivastava, Priyanka Gangwar, Ruchika Kapoor, Rakesh Mittal, Rama D. |
author_sort | Srivastava, Priyanka |
collection | PubMed |
description | Matrix metalloproteinases (MMPs) contribute to tumor invasion and microenvironment, hence are associated with bladder cancer risk. We therefore, tested whether polymorphisms in MMP genes modify the risk of bladder cancer (BC) and whether smoke exposure modifies this risk. Genotyping was performed in 200 BC patients and 200 controls by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). MMP1-1607 2G/2G and MMP7-181 GG genotype were associated with increased risk of BC (p <0.001; OR, 3.04; 95% CI1.71–5.39 and p, 0.005; OR, 2.38; 95% CI1.30–4.34) respectively. Smokers in BC patients showed significant increased risk for the same SNPs (p, 0.006; OR, 3.20; 95% CI1.40–7.31 and p, 0.009; OR, 2.85; 95% CI1.30–6.23 respectively). Haplotype analysis too revealed significant association with G/2G of MMP1-519-1607 (p < 0.001; OR, 2.62; 95% CI1.68–4.09). The 2G allele carrier (1G/2G + 2G/2G) of MMP1-1607 showed a protective effect and high recurrence free survival in Bacillus Calmette-Guerin (BCG) treated non muscle invasive BC (NMIBC) patients (log rank p, 0.030). Our datasuggested that MMP11607 2G and MMP7181 G allele were associated with high risk of BC, which was quite evident amongst smokers too. BCG treated NMIBC patients reflected protective effect for 2G allele carrier (1G/2G+2G/2G) of MMP1-1607. This study provided new support for the association of MMP1-1607 and MMP7-181 in bladder cancer development, the tumorigenic effect of which was observed to be more enhanced in case of tobacco exposure. |
format | Online Article Text |
id | pubmed-3835524 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | IOS Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-38355242013-12-10 Bladder Cancer Risk Associated with Genotypic Polymorphism of the Matrix Metalloproteinase-1 and 7 in North Indian Population Srivastava, Priyanka Gangwar, Ruchika Kapoor, Rakesh Mittal, Rama D. Dis Markers Other Matrix metalloproteinases (MMPs) contribute to tumor invasion and microenvironment, hence are associated with bladder cancer risk. We therefore, tested whether polymorphisms in MMP genes modify the risk of bladder cancer (BC) and whether smoke exposure modifies this risk. Genotyping was performed in 200 BC patients and 200 controls by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). MMP1-1607 2G/2G and MMP7-181 GG genotype were associated with increased risk of BC (p <0.001; OR, 3.04; 95% CI1.71–5.39 and p, 0.005; OR, 2.38; 95% CI1.30–4.34) respectively. Smokers in BC patients showed significant increased risk for the same SNPs (p, 0.006; OR, 3.20; 95% CI1.40–7.31 and p, 0.009; OR, 2.85; 95% CI1.30–6.23 respectively). Haplotype analysis too revealed significant association with G/2G of MMP1-519-1607 (p < 0.001; OR, 2.62; 95% CI1.68–4.09). The 2G allele carrier (1G/2G + 2G/2G) of MMP1-1607 showed a protective effect and high recurrence free survival in Bacillus Calmette-Guerin (BCG) treated non muscle invasive BC (NMIBC) patients (log rank p, 0.030). Our datasuggested that MMP11607 2G and MMP7181 G allele were associated with high risk of BC, which was quite evident amongst smokers too. BCG treated NMIBC patients reflected protective effect for 2G allele carrier (1G/2G+2G/2G) of MMP1-1607. This study provided new support for the association of MMP1-1607 and MMP7-181 in bladder cancer development, the tumorigenic effect of which was observed to be more enhanced in case of tobacco exposure. IOS Press 2010 2010-09-08 /pmc/articles/PMC3835524/ /pubmed/20826916 http://dx.doi.org/10.3233/DMA-2010-0724 Text en Copyright © 2010 Hindawi Publishing Corporation. |
spellingShingle | Other Srivastava, Priyanka Gangwar, Ruchika Kapoor, Rakesh Mittal, Rama D. Bladder Cancer Risk Associated with Genotypic Polymorphism of the Matrix Metalloproteinase-1 and 7 in North Indian Population |
title | Bladder Cancer Risk Associated with Genotypic Polymorphism of the Matrix Metalloproteinase-1 and 7 in North Indian Population |
title_full | Bladder Cancer Risk Associated with Genotypic Polymorphism of the Matrix Metalloproteinase-1 and 7 in North Indian Population |
title_fullStr | Bladder Cancer Risk Associated with Genotypic Polymorphism of the Matrix Metalloproteinase-1 and 7 in North Indian Population |
title_full_unstemmed | Bladder Cancer Risk Associated with Genotypic Polymorphism of the Matrix Metalloproteinase-1 and 7 in North Indian Population |
title_short | Bladder Cancer Risk Associated with Genotypic Polymorphism of the Matrix Metalloproteinase-1 and 7 in North Indian Population |
title_sort | bladder cancer risk associated with genotypic polymorphism of the matrix metalloproteinase-1 and 7 in north indian population |
topic | Other |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835524/ https://www.ncbi.nlm.nih.gov/pubmed/20826916 http://dx.doi.org/10.3233/DMA-2010-0724 |
work_keys_str_mv | AT srivastavapriyanka bladdercancerriskassociatedwithgenotypicpolymorphismofthematrixmetalloproteinase1and7innorthindianpopulation AT gangwarruchika bladdercancerriskassociatedwithgenotypicpolymorphismofthematrixmetalloproteinase1and7innorthindianpopulation AT kapoorrakesh bladdercancerriskassociatedwithgenotypicpolymorphismofthematrixmetalloproteinase1and7innorthindianpopulation AT mittalramad bladdercancerriskassociatedwithgenotypicpolymorphismofthematrixmetalloproteinase1and7innorthindianpopulation |