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Microglia: An Active Player in the Regulation of Synaptic Activity

Synaptic plasticity is critical for elaboration and adaptation in the developing and developed brain. It is well established that astrocytes play an important role in the maintenance of what has been dubbed “the tripartite synapse”. Increasing evidence shows that a fourth cell type, microglia, is cr...

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Detalles Bibliográficos
Autores principales: Ji, Kyungmin, Miyauchi, Jeremy, Tsirka, Stella E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835777/
https://www.ncbi.nlm.nih.gov/pubmed/24303218
http://dx.doi.org/10.1155/2013/627325
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author Ji, Kyungmin
Miyauchi, Jeremy
Tsirka, Stella E.
author_facet Ji, Kyungmin
Miyauchi, Jeremy
Tsirka, Stella E.
author_sort Ji, Kyungmin
collection PubMed
description Synaptic plasticity is critical for elaboration and adaptation in the developing and developed brain. It is well established that astrocytes play an important role in the maintenance of what has been dubbed “the tripartite synapse”. Increasing evidence shows that a fourth cell type, microglia, is critical to this maintenance as well. Microglia are the resident macrophages of the central nervous system (CNS). Because of their well-characterized inflammatory functions, research has primarily focused on their innate immune properties. The role of microglia in the maintenance of synapses in development and in homeostasis is not as well defined. A number of significant findings have shed light on the critical role of microglia at the synapse. It is becoming increasingly clear that microglia play a seminal role in proper synaptic development and elimination.
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spelling pubmed-38357772013-12-03 Microglia: An Active Player in the Regulation of Synaptic Activity Ji, Kyungmin Miyauchi, Jeremy Tsirka, Stella E. Neural Plast Review Article Synaptic plasticity is critical for elaboration and adaptation in the developing and developed brain. It is well established that astrocytes play an important role in the maintenance of what has been dubbed “the tripartite synapse”. Increasing evidence shows that a fourth cell type, microglia, is critical to this maintenance as well. Microglia are the resident macrophages of the central nervous system (CNS). Because of their well-characterized inflammatory functions, research has primarily focused on their innate immune properties. The role of microglia in the maintenance of synapses in development and in homeostasis is not as well defined. A number of significant findings have shed light on the critical role of microglia at the synapse. It is becoming increasingly clear that microglia play a seminal role in proper synaptic development and elimination. Hindawi Publishing Corporation 2013 2013-11-03 /pmc/articles/PMC3835777/ /pubmed/24303218 http://dx.doi.org/10.1155/2013/627325 Text en Copyright © 2013 Kyungmin Ji et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Ji, Kyungmin
Miyauchi, Jeremy
Tsirka, Stella E.
Microglia: An Active Player in the Regulation of Synaptic Activity
title Microglia: An Active Player in the Regulation of Synaptic Activity
title_full Microglia: An Active Player in the Regulation of Synaptic Activity
title_fullStr Microglia: An Active Player in the Regulation of Synaptic Activity
title_full_unstemmed Microglia: An Active Player in the Regulation of Synaptic Activity
title_short Microglia: An Active Player in the Regulation of Synaptic Activity
title_sort microglia: an active player in the regulation of synaptic activity
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835777/
https://www.ncbi.nlm.nih.gov/pubmed/24303218
http://dx.doi.org/10.1155/2013/627325
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