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Primary Neuroendocrine Carcinoma of Ocular Adnexa

We present our findings in a case of primary neuroendocrine carcinoma (NEC) of the lacrimal gland and a case of primary Merkel cell carcinoma (MCC) of the eyelid. An 86-year-old man noticed a swelling of the left upper eyelid three months earlier. We performed excision biopsy and histopathological e...

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Autores principales: Yamanouchi, Daisuke, Oshitari, Toshiyuki, Nakamura, Yosuke, Yotsukura, Jiro, Asanagi, Kaoru, Baba, Takayuki, Nizawa, Tomohiro, Kishimoto, Takashi, Yonemori, Yoko, Ota, Satoshi, Yamamoto, Shuichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835809/
https://www.ncbi.nlm.nih.gov/pubmed/24294530
http://dx.doi.org/10.1155/2013/281351
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author Yamanouchi, Daisuke
Oshitari, Toshiyuki
Nakamura, Yosuke
Yotsukura, Jiro
Asanagi, Kaoru
Baba, Takayuki
Nizawa, Tomohiro
Kishimoto, Takashi
Yonemori, Yoko
Ota, Satoshi
Yamamoto, Shuichi
author_facet Yamanouchi, Daisuke
Oshitari, Toshiyuki
Nakamura, Yosuke
Yotsukura, Jiro
Asanagi, Kaoru
Baba, Takayuki
Nizawa, Tomohiro
Kishimoto, Takashi
Yonemori, Yoko
Ota, Satoshi
Yamamoto, Shuichi
author_sort Yamanouchi, Daisuke
collection PubMed
description We present our findings in a case of primary neuroendocrine carcinoma (NEC) of the lacrimal gland and a case of primary Merkel cell carcinoma (MCC) of the eyelid. An 86-year-old man noticed a swelling of the left upper eyelid three months earlier. We performed excision biopsy and histopathological examination indicated that he had a primary NEC of the left lacrimal gland. He underwent chemotherapy followed by excision including the clinically visible margins and 50 Gy radiotherapy of the surgical margins. He had neither recurrence nor metastasis for 6 months since the last radiotherapy. An 80-year-old man noticed a nodule in the right upper eyelid and was referred to our hospital because the size was increasing rapidly. A complete surgical excision of the margins of the tumor was performed with histopathological confirmation of negative margins. The final diagnosis was a primary MCC of the right upper eyelid. After surgery, he underwent 50 Gy radiotherapy on the neck to prevent metastasis. No recurrence or metastasis was found for two years. Although primary NEC of the ocular adnexa is extremely rare, the tumor has high malignancy and readily metastasizes. Thus, combined therapy including surgery, radiotherapy, and/or chemotherapy is needed for complete management of NEC.
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spelling pubmed-38358092013-12-01 Primary Neuroendocrine Carcinoma of Ocular Adnexa Yamanouchi, Daisuke Oshitari, Toshiyuki Nakamura, Yosuke Yotsukura, Jiro Asanagi, Kaoru Baba, Takayuki Nizawa, Tomohiro Kishimoto, Takashi Yonemori, Yoko Ota, Satoshi Yamamoto, Shuichi Case Rep Ophthalmol Med Case Report We present our findings in a case of primary neuroendocrine carcinoma (NEC) of the lacrimal gland and a case of primary Merkel cell carcinoma (MCC) of the eyelid. An 86-year-old man noticed a swelling of the left upper eyelid three months earlier. We performed excision biopsy and histopathological examination indicated that he had a primary NEC of the left lacrimal gland. He underwent chemotherapy followed by excision including the clinically visible margins and 50 Gy radiotherapy of the surgical margins. He had neither recurrence nor metastasis for 6 months since the last radiotherapy. An 80-year-old man noticed a nodule in the right upper eyelid and was referred to our hospital because the size was increasing rapidly. A complete surgical excision of the margins of the tumor was performed with histopathological confirmation of negative margins. The final diagnosis was a primary MCC of the right upper eyelid. After surgery, he underwent 50 Gy radiotherapy on the neck to prevent metastasis. No recurrence or metastasis was found for two years. Although primary NEC of the ocular adnexa is extremely rare, the tumor has high malignancy and readily metastasizes. Thus, combined therapy including surgery, radiotherapy, and/or chemotherapy is needed for complete management of NEC. Hindawi Publishing Corporation 2013 2013-11-03 /pmc/articles/PMC3835809/ /pubmed/24294530 http://dx.doi.org/10.1155/2013/281351 Text en Copyright © 2013 Daisuke Yamanouchi et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Yamanouchi, Daisuke
Oshitari, Toshiyuki
Nakamura, Yosuke
Yotsukura, Jiro
Asanagi, Kaoru
Baba, Takayuki
Nizawa, Tomohiro
Kishimoto, Takashi
Yonemori, Yoko
Ota, Satoshi
Yamamoto, Shuichi
Primary Neuroendocrine Carcinoma of Ocular Adnexa
title Primary Neuroendocrine Carcinoma of Ocular Adnexa
title_full Primary Neuroendocrine Carcinoma of Ocular Adnexa
title_fullStr Primary Neuroendocrine Carcinoma of Ocular Adnexa
title_full_unstemmed Primary Neuroendocrine Carcinoma of Ocular Adnexa
title_short Primary Neuroendocrine Carcinoma of Ocular Adnexa
title_sort primary neuroendocrine carcinoma of ocular adnexa
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835809/
https://www.ncbi.nlm.nih.gov/pubmed/24294530
http://dx.doi.org/10.1155/2013/281351
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