Cargando…
Pediatric Multiple Sclerosis: Current Concepts and Consensus Definitions
Multiple sclerosis (MS), a chronic inflammatory autoimmune disease of the central nervous system (CNS) commonly diagnosed in adults, is being recognized increasingly in children. An estimated 1.7%–5.6% of all patients with MS have clinical symptoms before reaching the age of 18 years. In comparison...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835839/ https://www.ncbi.nlm.nih.gov/pubmed/24294520 http://dx.doi.org/10.1155/2013/673947 |
_version_ | 1782292216455102464 |
---|---|
author | Pena, Joaquin A. Lotze, Timothy E. |
author_facet | Pena, Joaquin A. Lotze, Timothy E. |
author_sort | Pena, Joaquin A. |
collection | PubMed |
description | Multiple sclerosis (MS), a chronic inflammatory autoimmune disease of the central nervous system (CNS) commonly diagnosed in adults, is being recognized increasingly in children. An estimated 1.7%–5.6% of all patients with MS have clinical symptoms before reaching the age of 18 years. In comparison with adults, the diagnosis of MS in children can be more difficult, being dismissed or misdiagnosed as other clinical disorders. Although adults and children share basic aspects of the disorder, children have distinctive clinical features, neuroimaging, laboratory, and courses of the disease. The 2010 McDonald criteria have simplified the requirements for establishing the diagnosis of MS and have been proposed to be applicable for the diagnosis of pediatric MS, mainly in children 12 years and older. This paper describes the distinctive features of common pediatric demyelinating disorders, including MS, and summarizes the most recent advances based on the available literature. |
format | Online Article Text |
id | pubmed-3835839 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-38358392013-12-01 Pediatric Multiple Sclerosis: Current Concepts and Consensus Definitions Pena, Joaquin A. Lotze, Timothy E. Autoimmune Dis Review Article Multiple sclerosis (MS), a chronic inflammatory autoimmune disease of the central nervous system (CNS) commonly diagnosed in adults, is being recognized increasingly in children. An estimated 1.7%–5.6% of all patients with MS have clinical symptoms before reaching the age of 18 years. In comparison with adults, the diagnosis of MS in children can be more difficult, being dismissed or misdiagnosed as other clinical disorders. Although adults and children share basic aspects of the disorder, children have distinctive clinical features, neuroimaging, laboratory, and courses of the disease. The 2010 McDonald criteria have simplified the requirements for establishing the diagnosis of MS and have been proposed to be applicable for the diagnosis of pediatric MS, mainly in children 12 years and older. This paper describes the distinctive features of common pediatric demyelinating disorders, including MS, and summarizes the most recent advances based on the available literature. Hindawi Publishing Corporation 2013 2013-11-02 /pmc/articles/PMC3835839/ /pubmed/24294520 http://dx.doi.org/10.1155/2013/673947 Text en Copyright © 2013 J. A. Pena and T. E. Lotze. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Pena, Joaquin A. Lotze, Timothy E. Pediatric Multiple Sclerosis: Current Concepts and Consensus Definitions |
title | Pediatric Multiple Sclerosis: Current Concepts and Consensus Definitions |
title_full | Pediatric Multiple Sclerosis: Current Concepts and Consensus Definitions |
title_fullStr | Pediatric Multiple Sclerosis: Current Concepts and Consensus Definitions |
title_full_unstemmed | Pediatric Multiple Sclerosis: Current Concepts and Consensus Definitions |
title_short | Pediatric Multiple Sclerosis: Current Concepts and Consensus Definitions |
title_sort | pediatric multiple sclerosis: current concepts and consensus definitions |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835839/ https://www.ncbi.nlm.nih.gov/pubmed/24294520 http://dx.doi.org/10.1155/2013/673947 |
work_keys_str_mv | AT penajoaquina pediatricmultiplesclerosiscurrentconceptsandconsensusdefinitions AT lotzetimothye pediatricmultiplesclerosiscurrentconceptsandconsensusdefinitions |