Application of EPR Spectroscopy to Examination of Free Radical Formation in Thermally Sterilized Flumetasone

Thermal formation of free radicals in flumetasone sterilized according to the pharmaceutical norms at 160, 170 and 180 °C was examined by electron paramagnetic resonance (EPR) spectroscopy. The microbiological analysis was done. Similar free radical concentrations were measured for flumetasone steri...

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Autores principales: Kościelniak-Ziemniak, Magdalena, Pilawa, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835947/
https://www.ncbi.nlm.nih.gov/pubmed/24273387
http://dx.doi.org/10.1007/s00723-013-0490-6
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author Kościelniak-Ziemniak, Magdalena
Pilawa, Barbara
author_facet Kościelniak-Ziemniak, Magdalena
Pilawa, Barbara
author_sort Kościelniak-Ziemniak, Magdalena
collection PubMed
description Thermal formation of free radicals in flumetasone sterilized according to the pharmaceutical norms at 160, 170 and 180 °C was examined by electron paramagnetic resonance (EPR) spectroscopy. The microbiological analysis was done. Similar free radical concentrations were measured for flumetasone sterilized at 160 and 170 °C. The concentration was considerably higher than that for flumetasone sterilized at 180 °C. Fast spin–lattice relaxation processes, homogeneously broadened EPR lines, and complex free radicals system characterize the heated flumetasone. Free radicals were not observed 30 days after thermal sterilization. Optimal temperatures of sterilization of flumetasone are 160 and 170 °C.
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spelling pubmed-38359472013-11-22 Application of EPR Spectroscopy to Examination of Free Radical Formation in Thermally Sterilized Flumetasone Kościelniak-Ziemniak, Magdalena Pilawa, Barbara Appl Magn Reson Article Thermal formation of free radicals in flumetasone sterilized according to the pharmaceutical norms at 160, 170 and 180 °C was examined by electron paramagnetic resonance (EPR) spectroscopy. The microbiological analysis was done. Similar free radical concentrations were measured for flumetasone sterilized at 160 and 170 °C. The concentration was considerably higher than that for flumetasone sterilized at 180 °C. Fast spin–lattice relaxation processes, homogeneously broadened EPR lines, and complex free radicals system characterize the heated flumetasone. Free radicals were not observed 30 days after thermal sterilization. Optimal temperatures of sterilization of flumetasone are 160 and 170 °C. Springer Vienna 2013-10-29 2013 /pmc/articles/PMC3835947/ /pubmed/24273387 http://dx.doi.org/10.1007/s00723-013-0490-6 Text en © The Author(s) 2013 https://creativecommons.org/licenses/by/2.0/ Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Article
Kościelniak-Ziemniak, Magdalena
Pilawa, Barbara
Application of EPR Spectroscopy to Examination of Free Radical Formation in Thermally Sterilized Flumetasone
title Application of EPR Spectroscopy to Examination of Free Radical Formation in Thermally Sterilized Flumetasone
title_full Application of EPR Spectroscopy to Examination of Free Radical Formation in Thermally Sterilized Flumetasone
title_fullStr Application of EPR Spectroscopy to Examination of Free Radical Formation in Thermally Sterilized Flumetasone
title_full_unstemmed Application of EPR Spectroscopy to Examination of Free Radical Formation in Thermally Sterilized Flumetasone
title_short Application of EPR Spectroscopy to Examination of Free Radical Formation in Thermally Sterilized Flumetasone
title_sort application of epr spectroscopy to examination of free radical formation in thermally sterilized flumetasone
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835947/
https://www.ncbi.nlm.nih.gov/pubmed/24273387
http://dx.doi.org/10.1007/s00723-013-0490-6
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