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Role of CT perfusion imaging in evaluating the effects of multiple burr hole surgery on adult ischemic Moyamoya disease
INTRODUCTION: To evaluate the effects of the multiple burr hole (MBH) revascularization on ischemic type adult Moyamoya disease (MMD) by computed tomography perfusion (CTP). METHODS: Eighty-six ischemic MMD patients received CTP 1 week before and 3 weeks after MBH operation. Fifty-seven patients rec...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835952/ https://www.ncbi.nlm.nih.gov/pubmed/24153446 http://dx.doi.org/10.1007/s00234-013-1291-1 |
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author | Dai, Dong Wei Zhao, Wen Yuan Zhang, Yong Wei Yang, Zhi Gang Li, Qiang Xu, Bing Ma, Xiao Long Tian, Bing Liu, Jian Min |
author_facet | Dai, Dong Wei Zhao, Wen Yuan Zhang, Yong Wei Yang, Zhi Gang Li, Qiang Xu, Bing Ma, Xiao Long Tian, Bing Liu, Jian Min |
author_sort | Dai, Dong Wei |
collection | PubMed |
description | INTRODUCTION: To evaluate the effects of the multiple burr hole (MBH) revascularization on ischemic type adult Moyamoya disease (MMD) by computed tomography perfusion (CTP). METHODS: Eighty-six ischemic MMD patients received CTP 1 week before and 3 weeks after MBH operation. Fifty-seven patients received it again at 6 month and underwent digital subtraction angiography (DSA) and mRS follow-up. Cerebral blood flow (CBF), cerebral blood volume (CBV), mean transit time (MTT), time to peak (TTP), and relative values of ischemic symptomatic hemispheres were measured. Differences in pre- and post-surgery perfusion CT values were assessed. RESULTS: There were significant differences of CBF, TTP, and relative time to peak (rTTP) in ischemic hemisphere between 1 week before and 3 weeks after surgery, and no significant difference in relative cerebral blood flow (rCBF), CBV, relative cerebral blood volume (rCBV), MTT, relative mean transit time (rMTT). According to whether there was symptom improvement or not on 3 weeks after MBH, the rTTP value was not statistically significant in the patients whose symptoms were not improved at all on 3 weeks after operation. Six-month follow-up showed that CBF, rCBF, and rCBV values were significantly higher than those before operation. Postoperative MTT, TTP, rMTT, and rTTP values were significantly lower than those before operation. CONCLUSION: CTP is a sensitive method to obtain functional imaging of cerebral microcirculation, which can be a noninvasive assessment of the abnormalities of intracranial arteries and cerebral perfusion changes in MMD before and after surgery. CBF and TTP map, especially the relative values of TTP, seems to have the capability of being quite sensitive to the presence of altered brain perfusion at early time after indirect revascularization. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00234-013-1291-1) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-3835952 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-38359522013-11-22 Role of CT perfusion imaging in evaluating the effects of multiple burr hole surgery on adult ischemic Moyamoya disease Dai, Dong Wei Zhao, Wen Yuan Zhang, Yong Wei Yang, Zhi Gang Li, Qiang Xu, Bing Ma, Xiao Long Tian, Bing Liu, Jian Min Neuroradiology Diagnostic Neuroradiology INTRODUCTION: To evaluate the effects of the multiple burr hole (MBH) revascularization on ischemic type adult Moyamoya disease (MMD) by computed tomography perfusion (CTP). METHODS: Eighty-six ischemic MMD patients received CTP 1 week before and 3 weeks after MBH operation. Fifty-seven patients received it again at 6 month and underwent digital subtraction angiography (DSA) and mRS follow-up. Cerebral blood flow (CBF), cerebral blood volume (CBV), mean transit time (MTT), time to peak (TTP), and relative values of ischemic symptomatic hemispheres were measured. Differences in pre- and post-surgery perfusion CT values were assessed. RESULTS: There were significant differences of CBF, TTP, and relative time to peak (rTTP) in ischemic hemisphere between 1 week before and 3 weeks after surgery, and no significant difference in relative cerebral blood flow (rCBF), CBV, relative cerebral blood volume (rCBV), MTT, relative mean transit time (rMTT). According to whether there was symptom improvement or not on 3 weeks after MBH, the rTTP value was not statistically significant in the patients whose symptoms were not improved at all on 3 weeks after operation. Six-month follow-up showed that CBF, rCBF, and rCBV values were significantly higher than those before operation. Postoperative MTT, TTP, rMTT, and rTTP values were significantly lower than those before operation. CONCLUSION: CTP is a sensitive method to obtain functional imaging of cerebral microcirculation, which can be a noninvasive assessment of the abnormalities of intracranial arteries and cerebral perfusion changes in MMD before and after surgery. CBF and TTP map, especially the relative values of TTP, seems to have the capability of being quite sensitive to the presence of altered brain perfusion at early time after indirect revascularization. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00234-013-1291-1) contains supplementary material, which is available to authorized users. Springer Berlin Heidelberg 2013-10-24 2013 /pmc/articles/PMC3835952/ /pubmed/24153446 http://dx.doi.org/10.1007/s00234-013-1291-1 Text en © The Author(s) 2013 https://creativecommons.org/licenses/by-nc/2.0/ Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. |
spellingShingle | Diagnostic Neuroradiology Dai, Dong Wei Zhao, Wen Yuan Zhang, Yong Wei Yang, Zhi Gang Li, Qiang Xu, Bing Ma, Xiao Long Tian, Bing Liu, Jian Min Role of CT perfusion imaging in evaluating the effects of multiple burr hole surgery on adult ischemic Moyamoya disease |
title | Role of CT perfusion imaging in evaluating the effects of multiple burr hole surgery on adult ischemic Moyamoya disease |
title_full | Role of CT perfusion imaging in evaluating the effects of multiple burr hole surgery on adult ischemic Moyamoya disease |
title_fullStr | Role of CT perfusion imaging in evaluating the effects of multiple burr hole surgery on adult ischemic Moyamoya disease |
title_full_unstemmed | Role of CT perfusion imaging in evaluating the effects of multiple burr hole surgery on adult ischemic Moyamoya disease |
title_short | Role of CT perfusion imaging in evaluating the effects of multiple burr hole surgery on adult ischemic Moyamoya disease |
title_sort | role of ct perfusion imaging in evaluating the effects of multiple burr hole surgery on adult ischemic moyamoya disease |
topic | Diagnostic Neuroradiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835952/ https://www.ncbi.nlm.nih.gov/pubmed/24153446 http://dx.doi.org/10.1007/s00234-013-1291-1 |
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