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Role of CT perfusion imaging in evaluating the effects of multiple burr hole surgery on adult ischemic Moyamoya disease

INTRODUCTION: To evaluate the effects of the multiple burr hole (MBH) revascularization on ischemic type adult Moyamoya disease (MMD) by computed tomography perfusion (CTP). METHODS: Eighty-six ischemic MMD patients received CTP 1 week before and 3 weeks after MBH operation. Fifty-seven patients rec...

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Autores principales: Dai, Dong Wei, Zhao, Wen Yuan, Zhang, Yong Wei, Yang, Zhi Gang, Li, Qiang, Xu, Bing, Ma, Xiao Long, Tian, Bing, Liu, Jian Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835952/
https://www.ncbi.nlm.nih.gov/pubmed/24153446
http://dx.doi.org/10.1007/s00234-013-1291-1
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author Dai, Dong Wei
Zhao, Wen Yuan
Zhang, Yong Wei
Yang, Zhi Gang
Li, Qiang
Xu, Bing
Ma, Xiao Long
Tian, Bing
Liu, Jian Min
author_facet Dai, Dong Wei
Zhao, Wen Yuan
Zhang, Yong Wei
Yang, Zhi Gang
Li, Qiang
Xu, Bing
Ma, Xiao Long
Tian, Bing
Liu, Jian Min
author_sort Dai, Dong Wei
collection PubMed
description INTRODUCTION: To evaluate the effects of the multiple burr hole (MBH) revascularization on ischemic type adult Moyamoya disease (MMD) by computed tomography perfusion (CTP). METHODS: Eighty-six ischemic MMD patients received CTP 1 week before and 3 weeks after MBH operation. Fifty-seven patients received it again at 6 month and underwent digital subtraction angiography (DSA) and mRS follow-up. Cerebral blood flow (CBF), cerebral blood volume (CBV), mean transit time (MTT), time to peak (TTP), and relative values of ischemic symptomatic hemispheres were measured. Differences in pre- and post-surgery perfusion CT values were assessed. RESULTS: There were significant differences of CBF, TTP, and relative time to peak (rTTP) in ischemic hemisphere between 1 week before and 3 weeks after surgery, and no significant difference in relative cerebral blood flow (rCBF), CBV, relative cerebral blood volume (rCBV), MTT, relative mean transit time (rMTT). According to whether there was symptom improvement or not on 3 weeks after MBH, the rTTP value was not statistically significant in the patients whose symptoms were not improved at all on 3 weeks after operation. Six-month follow-up showed that CBF, rCBF, and rCBV values were significantly higher than those before operation. Postoperative MTT, TTP, rMTT, and rTTP values were significantly lower than those before operation. CONCLUSION: CTP is a sensitive method to obtain functional imaging of cerebral microcirculation, which can be a noninvasive assessment of the abnormalities of intracranial arteries and cerebral perfusion changes in MMD before and after surgery. CBF and TTP map, especially the relative values of TTP, seems to have the capability of being quite sensitive to the presence of altered brain perfusion at early time after indirect revascularization. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00234-013-1291-1) contains supplementary material, which is available to authorized users.
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spelling pubmed-38359522013-11-22 Role of CT perfusion imaging in evaluating the effects of multiple burr hole surgery on adult ischemic Moyamoya disease Dai, Dong Wei Zhao, Wen Yuan Zhang, Yong Wei Yang, Zhi Gang Li, Qiang Xu, Bing Ma, Xiao Long Tian, Bing Liu, Jian Min Neuroradiology Diagnostic Neuroradiology INTRODUCTION: To evaluate the effects of the multiple burr hole (MBH) revascularization on ischemic type adult Moyamoya disease (MMD) by computed tomography perfusion (CTP). METHODS: Eighty-six ischemic MMD patients received CTP 1 week before and 3 weeks after MBH operation. Fifty-seven patients received it again at 6 month and underwent digital subtraction angiography (DSA) and mRS follow-up. Cerebral blood flow (CBF), cerebral blood volume (CBV), mean transit time (MTT), time to peak (TTP), and relative values of ischemic symptomatic hemispheres were measured. Differences in pre- and post-surgery perfusion CT values were assessed. RESULTS: There were significant differences of CBF, TTP, and relative time to peak (rTTP) in ischemic hemisphere between 1 week before and 3 weeks after surgery, and no significant difference in relative cerebral blood flow (rCBF), CBV, relative cerebral blood volume (rCBV), MTT, relative mean transit time (rMTT). According to whether there was symptom improvement or not on 3 weeks after MBH, the rTTP value was not statistically significant in the patients whose symptoms were not improved at all on 3 weeks after operation. Six-month follow-up showed that CBF, rCBF, and rCBV values were significantly higher than those before operation. Postoperative MTT, TTP, rMTT, and rTTP values were significantly lower than those before operation. CONCLUSION: CTP is a sensitive method to obtain functional imaging of cerebral microcirculation, which can be a noninvasive assessment of the abnormalities of intracranial arteries and cerebral perfusion changes in MMD before and after surgery. CBF and TTP map, especially the relative values of TTP, seems to have the capability of being quite sensitive to the presence of altered brain perfusion at early time after indirect revascularization. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00234-013-1291-1) contains supplementary material, which is available to authorized users. Springer Berlin Heidelberg 2013-10-24 2013 /pmc/articles/PMC3835952/ /pubmed/24153446 http://dx.doi.org/10.1007/s00234-013-1291-1 Text en © The Author(s) 2013 https://creativecommons.org/licenses/by-nc/2.0/ Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Diagnostic Neuroradiology
Dai, Dong Wei
Zhao, Wen Yuan
Zhang, Yong Wei
Yang, Zhi Gang
Li, Qiang
Xu, Bing
Ma, Xiao Long
Tian, Bing
Liu, Jian Min
Role of CT perfusion imaging in evaluating the effects of multiple burr hole surgery on adult ischemic Moyamoya disease
title Role of CT perfusion imaging in evaluating the effects of multiple burr hole surgery on adult ischemic Moyamoya disease
title_full Role of CT perfusion imaging in evaluating the effects of multiple burr hole surgery on adult ischemic Moyamoya disease
title_fullStr Role of CT perfusion imaging in evaluating the effects of multiple burr hole surgery on adult ischemic Moyamoya disease
title_full_unstemmed Role of CT perfusion imaging in evaluating the effects of multiple burr hole surgery on adult ischemic Moyamoya disease
title_short Role of CT perfusion imaging in evaluating the effects of multiple burr hole surgery on adult ischemic Moyamoya disease
title_sort role of ct perfusion imaging in evaluating the effects of multiple burr hole surgery on adult ischemic moyamoya disease
topic Diagnostic Neuroradiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835952/
https://www.ncbi.nlm.nih.gov/pubmed/24153446
http://dx.doi.org/10.1007/s00234-013-1291-1
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